Multidisciplinary Training Program in Lung Disease

这项申请是对现有多学科培训计划的竞争性更新 在肺部疾病(HL07749)中，自1993年以来一直得到资助。的目标是 该计划是培养杰出的生物医学科学家，他们研究这种现象， 肺部疾病的机制、预防和治疗。该计划提议 支持12名博士后研究员(医学博士、博士和医学博士/博士)每年。调查性的 学员可采用的方法包括适用于分子、细胞、组织、 器官、整个动物和临床种群水平。该项目真正是多学科的，利用 来自医学院、公共卫生学院、药学院和 密歇根大学工程学院。主要成员之间的密切关系 导师和一位共同导师(S)与学员是培训体验的基础。这 研究经验的补充是一组核心的讲座、研讨会、核心会议、 以及在负责任的研究指导、职业规划、沟通技能和拨款方面的培训 写作。重点放在专门为个别受训人员设计的个人指导上。 增加了教员和核心讲座，以进一步巩固生物信息学的学科。 遗传学/表观遗传学、代谢组学和微生物组。新兴增长领域包括主机- 微生物相互作用，移植生物学，再生医学，精确医学，数据 科学、卫生服务研究和针对疾病的多机构临床网络 研究。博士后实习生可以获得临床研究设计和硕士学位 公共卫生学院的统计分析或卫生服务研究通过 国家健康与保健研究临床学者计划。范围广泛的 学员可选择的研究课题包括急性和慢性肺部疾病的病理生物学， 宿主防御机制，祖细胞生物学，生物信息学，肺的长期结果 疾病和危重疾病，医生决策，成本/收益分析，医疗应用 技术和实施科学。研究员和导师由一个委员会审查，该委员会 监督研究员的培训和职业发展。八个代表不足的少数族裔 完成了我们过去10年的培训计划。90%的毕业生在 过去的15年是在学术或行业的职位，这表明了该项目的成功。

This application is a competitive renewal of the present Multidisciplinary Training Program in Lung Disease (HL07749), which has been continuously funded since 1993. The goal of the program is produce outstanding biomedical scientists who investigate the manifestations, mechanisms, prevention, and treatment of pulmonary disorders. The program proposes to support 12 postdoctoral fellows (M.D., Ph.D., and M.D./PhD.) per year. The investigative approaches available to trainees include disciplines applicable at the molecular, cellular, tissue, organ, whole animal and clinical population levels. The program is truly multidisciplinary, utilizing faculty trainers from the Medical School, School of Public Health, the College of Pharmacy, and the College of Engineering at the University of Michigan. A close relationship between a primary mentor and a co-mentor(s) with the trainee is the foundation of the training experience. This research experience is supplemented by a core group of lectures, workshops, core conferences, and training in responsible research conduct, career planning, communication skills, and grant writing. Emphasis is placed on personal instruction specifically designed for individual trainees. Faculty and core lectures have been added to further solidify the disciplines of bioinformatics, genetics/epigenetics, metabolomics, and the microbiome. Emerging areas of growth include host- microbe interactions, transplantation biology, regenerative medicine, precision medicine, data science, health services research and multi-institutional disease-specific clinical networks for research. Postdoctoral trainees can acquire Master's Degrees in Clinical Research Design and Statistical Analysis from the School of Public Health or health services research through the National Clinical Scholars Program in Health and Healthcare Research. A broad range of research topics is available to trainees including the pathobiology of acute and chronic lung disease, host defense mechanisms, progenitor cell biology, bioinformatics, long-term outcomes in lung disease and critical illness, physician decision making, cost/benefit analysis, application of medical technology and implementation science. Fellows and mentors are reviewed by a committee that monitors the training and career development of fellows. Eight underrepresented minorities have completed our training program over the past 10 years. Ninety percent of graduates trained in the past 15 years are in academic or industry positions, indicative of the program's success.