BU Clinical HIV/AIDS Research Training Program (BU-CHART

项目摘要/摘要 波士顿大学临床艾滋病毒/艾滋病研究培训(BU-CHART)计划为杰出的医学博士做准备 和博士生，作为艾滋病毒/艾滋病研究的科学领导者，专注于 弱势和未得到充分服务的人群。BU-CHART将其培训计划重点放在四个高度优先的艾滋病毒 应对在结束艾滋病毒流行方面仍然存在的重大挑战的研究领域：1)实质 使用和艾滋病毒-物质使用障碍和艾滋病毒感染的综合体助长了美国艾滋病毒的爆发， 东欧和亚洲。2)结核病和丙型肝炎病毒合并感染--包括结核病和 丙型肝炎病毒是艾滋病毒感染者死亡的主要原因；3)艾滋病毒传播和 潜伏期的建立-艾滋病毒发病率仍然顽固地居高不下，并及早建立艾滋病毒潜伏期 仍然是一个令人沮丧的谜题，限制了寻找艾滋病毒治愈的进展；4)艾滋病毒治疗和加速 衰老过程-我们仍在寻求安全有效的干预措施，以减少不适当的免疫激活 伴随着艾滋病毒感染并导致终末器官疾病。培训设施包括最先进的 波士顿大学医学院和公共卫生学院以及波士顿医学中心的研究空间 新英格兰最大的安全网医院。BU-CHART与校园内现有的培训计划相结合， 包括波士顿大学临床和翻译科学研究所(CTSI)、普罗维登斯-波士顿艾滋病中心 研究，以及北大校区由T32和R25资助的其他培训项目。我们结对了我们杰出的 BU-CHART教师导师的实习生，他们是NIH资助的研究项目的知名研究人员 并体验指导。我们提供了一个精心设计的科学推理和培训计划 实验设计、专业发展和人类研究的道德行为。结果是一个 培训成功的跟踪记录。在过去的15年里，北大查特培养了26名博士和博士后 研究员，其中20人(77%)仍在专注于艾滋病毒研究的学术职位。在7名实习生中 在本赠款周期内完成该计划的人中，6人现在担任学术研究职位，3人 已获得职业发展奖的有2人，目前正在审查职业发展奖。

PROJECT SUMMARY/ABSTRACT The Boston University Clinical HIV/AIDS Research Training (BU-CHART) program prepares outstanding M.D and Ph.D. trainees for careers as scientific leaders in HIV/AIDS research, with a focus on research in disadvantaged and underserved populations. BU-CHART focuses its training plan on four high-priority HIV research fields that address the substantial challenges that remain to ending the HIV epidemic: 1) substance use and HIV - a syndemic of substance use disorders and HIV infection fuels HIV outbreaks in the U.S., Eastern Europe, and Asia. 2) Tuberculosis and HCV co-infection - comorbidities, including Tuberculosis and Hepatitis C Virus are leading causes of death among HIV-infected people; 3) HIV transmission and establishment of latency - HIV incidence remains stubbornly elevated, and early establishment of HIV latency remains a frustrating puzzle that limits progress to finding HIV cure; 4) HIV treatment and the accelerated aging process - we still seek safe and effective interventions to reduce the inappropriate immune activation that accompanies HIV infection and leads to end-organ disease. The training facilities include state-of-the-art research space at Boston University Schools of Medicine and Public Health and Boston Medical Center, the largest Safety-net hospital in New England. BU-CHART synergizes with existing training programs on campus, including the BU Clinical and Translational Science Institute (CTSI), the Providence-Boston Center for AIDS Research, and other T32- and R25-funded training programs on the BUMC campus. We pair our outstanding trainees with BU-CHART faculty mentors who are established investigators with NIH-funded research projects and experience mentoring. We provide a thoughtfully constructed training plan in scientific reasoning and experimental design, professional development, and the ethical conduct of human research. The result is a track record of training success. In the past 15 years, BU-CHART trained 26 MD and PhD post-doctoral fellows, of whom 20 (77%) remain in in academic positions focused on HIV research. Among the 7 trainees who completed the program in the current grant cycle, 6 now have academic research positions, 3 have already obtained career development awards, and 2 have career development awards currently under review.