LSU Superfund Research Center - Environmentally Persistent Free Radicals

项目摘要/摘要：总体 近5300万人(占美国人口的17%；5岁以下儿童的18%)居住在离超级基金3英里的范围内 补救地点。超级基金网站含有各种各样的污染物，包括有机化学品、金属、碳- 泥质材料和二氧化硅。尽管这些成分中的每一种都能对生物体造成损害，但它们的潜力- 将TiAl结合成独特的危险试剂一直未得到充分研究。有趣的是，当这些特工 它们被送到一起，特别是在热修复期间，它们结合在一起形成颗粒物(PM)和化学- 在环境中持续存在但仍具有生物活性的被吸附的自由基。我们称这些为污染物颗粒。 系统环境持久性自由基(EPFR)。在热处理过程中产生电子顺磁共振。 危险废物和近30%的超级基金场地(不包括地下水)通过热处理进行修复- 门槛。超级基金站点附近的EPFR浓度范围为1x1018-4x1019 EPFR/g(自转/g)PM这个建议- 大量美国居民暴露在含有EPFR的PM中。路易斯安那州立大学超级基金研究中心 研究人员已经证明，这些EPFR 1)在暴露的宿主中引起心脏和肺功能障碍，2) 如果存在于家庭粉尘中，则与儿童目前的喘息有关，以及3)是形成- 二恶英等新污染物的转化。我们的中心现在试图了解EPFR是如何诱导肺- 神经/心血管功能障碍以及如何减少EPFR的形成，促进EPFR的衰退，并限制暴露 到EPFR，最终目标是改善人类健康和环境。我们将确定EPFR如何 形成、稳定和腐烂以及它们如何催化循环产生羟基自由基。这件事会做到的 使用一套先进的表面和化学分析。由于呼吸道是进入环境的主要部位- 心理PM，我们将展示EPFR暴露与使用ES的儿童呼吸健康不良之间的联系- 建立以社区为基础的出生队列。我们将探讨EPFR诱导哮喘和心血管疾病的机制。 使用吸入暴露的小鼠模型制作眼部疾病。支持核心(管理、数据管理和 分析、社区参与、研究经验和培训协调、材料和吸入 毒理学)将提供必要的集中试剂/服务和技术资源，从而 数据的准确性和工作的经济性，并促进跨学科活动。为了确保成功，这些领域的专家 各领域作为一个外部咨询委员会汇聚在一起，为该中心提供咨询。化学反应 和EPFR的物理学，更不用说它们对健康的影响了，人们对此知之甚少，而且是一种跨学科的方法 是处理关键研究领域所必需的。

Project Summary/Abstract: Overall Nearly 53 million people (17% of the US population; 18% of children <5 yrs) live within 3 miles of a Superfund remediation site. Superfund sites contain a wide variety of pollutants, including organic chemicals, metals, carbo- naceous material and silica. Although each of these components is capable of damage to organisms, their poten- tial to combine into unique hazardous agents has been understudied. Interestingly, when these agents are pre- sent together, particularly during thermal remediation, they combine to form particulate matter (PM) with chemi- sorbed free radicals that persist in the environment and yet are biologically active. We call these pollutant-particle systems environmentally persistent free radicals (EPFRs). EPFRs are produced during thermal treatment of haz- ardous wastes and nearly 30% of all Superfund sites (excluding groundwater) are remediated by thermal treat- ment. EPFR concentrations near Superfund sites range from 1x1018-4x1019 EPFRs/g (spins/g) of PM. This sug- gests a vast number of US residents are exposed to PM containing EPFRs. LSU Superfund Research Center researchers have shown that these EPFRs 1) induce cardiac and pulmonary dysfunction in the exposed host, 2) are associated with current wheeze in children if present in household dust, and 3) are intermediates in the for- mation of new pollutants such as dioxins. Our Center now seeks to understand how EPFRs induce pulmo- nary/cardiovascular dysfunction and how to attenuate EPFR formation, facilitate EPFR decay, and limit exposure to EPFRs, with the ultimate goal of improving human health and the environment. We will determine how EPFRs are formed, stabilized, and decay and how they catalytically cycle to produce hydroxyl radicals. This will be done using a suite of advanced surface and chemical analyses. Since the airway is a major site of entry of environ- mental PM, we will demonstrate a link between EPFR exposure and poor respiratory health in children using es- tablished community-based birth cohorts. We will explore mechanisms of EPFR-induced asthma and cardiovas- cular disease using mouse models exposed by inhalation. Support cores (Administration, Data Management & Analysis, Community Engagement, Research Experience and Training Coordination, Materials, and Inhalation Toxicology) will provide essential, centralized reagents/services and technological resources allowing for precision of data and economy of effort, and foster interdisciplinary activities. To ensure success, experts in these respective fields were brought together as an External Advisory Committee to advise this Center. The chemistry and physics of EPFRs, let alone their health impacts, are poorly understood, and an interdisciplinary approach is required to address the critical research areas.