Michigan Integrative Musculoskeletal Health Core Center (Overall Application)

密歇根州综合肌肉骨骼健康核心中心-概述 项目摘要 肌肉骨骼疾病仍然是一个巨大的公共医疗问题，占50%以上 发达国家的慢性病。当前的金融格局不仅对调查人员提出了挑战- 领导科学计划，但特别威胁合作研究，因为个人缺乏灵活性 预算限制了与我们的科学邻居分享有价值的技术的资源和能力。密歇根州 综合性肌肉骨骼健康核心中心(MiMHC)实现垂直集成、多尺度 肌肉骨骼科学从分子和基因组水平的机制到机体功能和临床 通过增加获得关键的专门资源和专业知识取得成果，这些资源和专业知识对 90名中心研究人员的肌肉骨骼研究项目。MiMHC的结构与 密歇根大学的倡议旨在促进跨学科和基础学科之间的合作 科学家和临床医生通过更好地了解疾病和损伤机制来促进健康。MiMHC 不仅提升了一批优秀的肌肉骨骼研究人员的能力，还利用 通过一个促进新奇和新兴肌肉骨骼的丰富计划，他们的集体才华 研究生命过程中的跨组织相互作用和性别差异。外展 该计划通过一个新颖的月度研讨会系列创建了一个丰富的肌肉骨骼科学家社区 建立在加速讨论、批判性思维、研究严谨性和重复性的现有势头基础上， 和创新。为了实现这些目标，一个行政核心将监督核心业务和三个 提供结构、组成和组织学服务、功能评估服务的资源核心， 并为MiMHC研究社区的所有成员提供综合数据分析服务。资源核心 的结构是为了促进从分子和基因组水平通过 器官水平和临床环境。对资源核心的访问一直是，并将继续是财政上的 并通过集中核心技术和通过提供访问 核心董事，他们是各自领域的专家，将就最佳技术选择提供指导， 实验设计，数据解释。UM环境非常适合继续构建强大的 并维持旨在增进对以下问题的理解的创新和合作风险 肌肉骨骼健康和疾病，并开展与NIAMS任务高度相关的科学。

Michigan Integrative Musculoskeletal Health Core Center - Overview Project Summary Musculoskeletal disorders remain an enormous public healthcare problem, accounting for more than fifty percent of chronic conditions in developed countries. The current financial landscape not only challenges investigator- led scientific programs, but particularly threatens collaborative research because lack of flexibility in individual budgets restricts resources and ability to share valuable techniques with our scientific neighbors. The Michigan Integrative Musculoskeletal Health Core Center (MiMHC) enables vertically integrated, multi-scale musculoskeletal science from molecular and omic-level mechanisms to organismal function and clinical outcomes by increasing access to critical, specialized resources and expertise that are fundamental to the musculoskeletal research programs of 90 Center investigators. The MiMHC is structured to be consistent with initiatives at the University of Michigan aimed at promoting collaborations across disciplines and between basic scientists and clinicians to promote health by better understanding disease and injury mechanisms. The MiMHC not only enhances the capabilities of a group of outstanding musculoskeletal researchers but also leverages their collective talent through an Enrichment Program that promotes novel and emerging musculoskeletal research in cross-tissue interactions and sex-specific differences throughout the life course. An outreach program creates a rich community of musculoskeletal scientists through a novel monthly seminar series that builds on existing momentum toward accelerating discussion, critical thinking, research rigor and reproducibility, and innovation. To accomplish these goals, an Administrative Core will oversee core operations and three Resource Cores to provide Structure, Composition, and Histology services, Functional assessment services, and Integrative Data Analytics services to all members of the MiMHC research community. The Resource Cores are structured to facilitate hierarchically mechanistic studies from the molecular and omic-levels through the organ-level and to the clinical setting. Access to the Resource Cores has been and will continue to be financially and scientifically impactful to Center investigators by centralizing core technologies and by providing access to Core Directors who are experts in their field and who will provide guidance on the best choice of technologies, experimental design, and data interpretation. The UM environment is ideal for continuing to build a strong research community and to sustain an innovative, collaborative venture aimed at advancing understanding of musculoskeletal health and disease and to conduct science highly relevant to the NIAMS mission.