Administrative Core - Core A

密歇根州综合肌肉骨骼健康核心中心-核心A 项目摘要 密歇根综合肌肉骨骼健康核心中心(MiMHC)将提供杰出的、最先进的 支持旨在了解肌肉骨骼机制的研究项目的资源和培训 健康和疾病。MiMHC的结构与UM旨在促进 跨学科的互动，以治疗复杂的疾病和促进医疗保健。就像大学一样， MiMHC还认识到，发起和维持协作文化对于实现高影响力至关重要 这些研究将极大地促进我们对疾病和损伤机制的理解。要实现 MiMHC目标，一个行政核心将提供领导和行政支持，从而确保 资源核心成功完成其使命，使研究界能够进行严格的 与NIAMS任务高度相关的多学科研究。行政核心将完成 它的目标通过执行三个目标来实现。首先，行政核心将建立、管理和 为资源核心提供指导，使其能够提供最先进的技术和专门的 通常不能通过机构核心获得但需要支持中心调查人员的分析 研究骨骼、肌肉、肌腱、韧带、软骨和末端。第二，行政核心将履行 监督核心运营，并提供持续提高有效性所需的反馈 资源核心增强了中心研究人员的科学计划。第三，浓缩计划将 促进基础科学家和临床医生之间的更大互动，支持初级医生的职业发展 研究人员建立肌肉骨骼健康研究计划，并通过外展扩大成员 计划、教育和开发新技术，供肌肉骨骼研究人员和 他们的合作者。此外，行政核心将建立一个试点计划，以促进新的基本知识 肌肉骨骼研究的重点是跨组织的相互作用和性别差异以及新兴的 翻译研究。来自中心调查人员的持续反馈和定期中心会议将使 行政核心要具有适应性和有效性，以最好地使调查人员能够进行杰出的研究， 创建丰富的肌肉骨骼科学家社区，促进肌肉骨骼科学家之间的新合作 研究人员加速了解肌肉骨骼的健康、损伤和疾病机制。

Michigan Integrative Musculoskeletal Health Core Center – Core A Project Summary The Michigan Integrative Musculoskeletal Health Core Center (MiMHC) will provide outstanding, state-of-the-art resources and training to support research programs aimed at understanding mechanisms of musculoskeletal health and disease. The MiMHC is structured to be consistent with broader initiatives at UM aimed at promoting interactions across disciplines to treat complex diseases and to advance healthcare. Like the University, the MiMHC also recognizes that initiating and sustaining a culture of collaboration is essential for high impact research that will significantly advance our understanding of mechanisms of disease and injury. To achieve MiMHC goals, an Administrative Core will provide leadership and administrative support, thereby insuring success of the Resource Cores in their mission to enable the Research Community to conduct rigorous multidisciplinary research that is highly relevant to the NIAMS mission. The Administrative Core will accomplish its objectives through the execution of three Aims. First, the Administrative Core will establish, administer, and provide guidance to the Resource Cores to allow them to offer state of the art technologies and specialized assays that are generally not available through institutional cores but are needed to support center investigators studying bone, muscle, tendon, ligament, cartilage, and enthesis. Second, the Administrative Core will perform oversight of Core operations and provide the feedback needed to continually increase the effectiveness by which the Resource Cores enhance the scientific programs of Center investigators. Third, an Enrichment Program will promote greater interactions between basic scientists and clinicians, support career development of junior investigators building research programs in musculoskeletal health, and expand membership through outreach programs, education, and the development of new technologies for use by musculoskeletal researchers and their collaborators. In addition, the Administrative Core will establish a pilot program to promote novel basic musculoskeletal research focused on cross-tissue interactions and sex-specific differences as well as emerging translational research. Continual feedback from Center investigators and regular Center meetings will allow the Administrative Core to be adaptable and effective to best enable investigators to conduct outstanding research, create a rich community of musculoskeletal scientists, and promote new collaborations among musculoskeletal researchers to accelerate understanding of musculoskeletal health, injury and disease mechanisms.