California National Primate Research Center

概述 摘要 加州大学戴维斯分校的加州国家灵长类研究中心(CNPRC)， 请求资金延长下一个五年期(2018年5月1日)的基本业务补助金#P51-OD011107 至2023年4月30日)。目前处于运营的第56个年头，CNPRC为NIH支持的一系列 全国范围内的调查人员和行业合作伙伴。从成立到本年度，中国石油天然气集团公司一直 通过提供高质量的动物、设施、工具和服务，高度响应研究社区 在核心科学家为我们的使命服务的智力基础设施的推动下：“改善人类 通过支持特殊的非人类灵长类研究项目，提高健康和生活质量“。的目标 下一个资助期体现在以下具体目标上：(1)进行最先进的研究和 利用非人类灵长类动物模型对人类疾病的理解和治疗做出科学贡献 跨年龄段，(2)为研究人员提供卓越的非人灵长类专业知识和服务 地方、地区和国家层面，以促进NIH支持的卓越研究，(3)指导和培训 拥有非人灵长类专业知识的下一代翻译调查人员，以及(4)确保最高 负责任的研究和动物护理行为的标准。我们将继续强调团队科学 旨在解决人类一生中的主要健康问题，目标是超越传统的 跨学科的努力，使正在解决的研究问题真正趋同。请求支持 行政事务(主任办公室、行政和业务事务、信息技术 服务，设施改善)，灵长类服务(群体管理和研究服务，国家 老龄群体研究所，灵长类医学服务，解剖和临床病理服务，人口和 行为健康服务、遗传学管理服务)、服务核心(流式细胞术、吸入法 暴露、多模式成像、灵长类分析实验室)、科研单位(传染病、 神经科学和行为学、生殖科学和再生医学、呼吸系统疾病)，以及 外展、先导研究计划和NPRC联盟活动。我们的总体目标是实现 通过CNPRC的临床前计划以及通过协作团队产生的翻译影响 覆盖当地、全国和全球。我们致力于开发和提供广泛的 最大限度地利用非人类灵长类动物模型来改善人类健康的研究机会。这个 加州大学戴维斯分校对中国人民共和国的机构承诺得到加强，这将促进我们的 在推动非人类灵长类研究进入下一个融合生物医学研究时代中的作用。

OVERVIEW ABSTRACT The California National Primate Research Center (CNPRC), located at the University of California, Davis, requests funds to renew the base operating grant #P51-OD011107 for the next five year period (May 1, 2018 through April 30, 2023). Currently in the 56th year of operation, the CNPRC serves a range of NIH-supported investigators and industry partners nationwide. From inception through the current year, the CNPRC has been highly responsive to the research community by providing high quality animals, facilities, tools, and services driven by the intellectual infrastructure of the Core Scientists in the service of our Mission: “To improve human health and quality of life through support of exceptional nonhuman primate research programs”. The goals for the next funding period are reflected in the following Specific Aims: (1) Conduct state-of-the-art research and scientifically contribute to the understanding and treatment of human disease with nonhuman primate models across the age spectrum, (2) Provide exceptional nonhuman primate expertise and services to investigators at the local, regional, and national levels to advance NIH-supported research excellence, (3) Mentor and train the next generation of translational investigators with nonhuman primate expertise, and (4) Ensure the highest standards of responsible conduct of research and animal care. We will continue to emphasize team science aimed at major human health problems across the lifespan, with the goal of moving beyond traditional interdisciplinary efforts to true convergence on the research problems being addressed. Support is requested for Administrative Services (Director's Office, Administration and Operations Services, Information Technology Services, Facilities Improvement), Primate Services (Colony Management and Research Services, National Institute on Aging Colony, Primate Medicine Services, Anatomic and Clinical Pathology Services, Population and Behavioral Health Services, Genetics Management Services), Service Cores (Flow Cytometry, Inhalation Exposure, Multimodal Imaging, Primate Assay Laboratory), Scientific Research Units (Infectious Diseases, Neuroscience and Behavior, Reproductive Sciences and Regenerative Medicine, Respiratory Diseases), and for Outreach, the Pilot Research Program, and NPRC Consortium activities. Our over-arching goal is to achieve translational impact through preclinical programs housed at the CNPRC as well as through collaborative teams that reach out locally, nationally, and globally. We are committed to developing and providing a wide range of research opportunities that maximize use of the nonhuman primate model to improve human health. The institutional commitment from UC Davis to the CNPRC has been reinforced in a manner that will facilitate our role in moving nonhuman primate research into the next era of convergent biomedical research.