Human Tissues Biobank Core

项目摘要/摘要：人体组织生物库核心 缺乏从特征良好的患者那里获得经过验证的、高质量的人类细胞和组织是其中之一 开展人类皮肤病研究的最大障碍。人体组织生物库的核心地址 这一未得到满足的关键需求，汇集了一系列独特而强大的资源，将使皮肤病 调查人员在任何地理位置，附属于任何学术机构，以获得高度 经过验证的高质量人体组织，目标是支持和支持高质量的翻译人类 皮肤病研究。Biobank Core允许访问临床信息、DNA、血清、血浆和 超过11.3万名特征明确的患者的基因分型结果，他们的医疗记录，他们的基因分型 结果以及将这些患者召回进行进一步研究的能力。还向150多万人提供访问权限 保存病理标本，有能力在获得IRB适当批准的情况下访问医疗记录。活生生 患者和病理标本都可以通过诊断进行搜索，皮肤病也得到了很好的代表。 Core还提供新鲜切除的健康成人皮肤和新生儿包皮以及可存活的 从人类皮肤中获得的纯化细胞群体。最后，核心提供了免疫缺陷的NSG小鼠 移植了人的皮肤和血液。这些小鼠可以在可接近的动物模型中研究活体人类皮肤 对研究局部药物传递、活体皮肤信号传递、T细胞向皮肤的转运、 常驻记忆T细胞生成、移植物抗宿主病和皮肤纤维化。核心还提供IRB 起草和支持议定书，以及外部调查人员利用这些服务所需的所有服务 资源。研究界可能由任何机构的任何调查员组成，他们希望 开展基于人体细胞和组织的研究。我们提供来自40名研究人员的科学项目，他们希望 利用这一核心的服务。总而言之，Biobank核心提供了高度个性化的生活方式 病人、银行病理标本、新鲜人类皮肤和移植人的免疫缺陷小鼠 皮肤和鲜血。生物库核心的目标是为任何人提供获取高质量人体组织的途径 以加速人类皮肤病研究为目标的任何机构的研究人员。

Project Summary/Abstract: Human Tissues Biobank Core Lack of access to validated, high quality human cells and tissues from well-characterized patients is one of the greatest barriers to carrying out human skin disease research. The Human Tissues Biobank Core addresses this unmet critical need, bringing together a set of unique and powerful resources that will allow skin disease investigators at any geographic location, affiliated with any academic institution, to gain access to highly validated, high quality human tissues with the goal of enabling and supporting high-quality translational human skin disease research. The Biobank Core allows access to clinical information, DNA, serum, plasma, and genotyping results from over 113,000 well characterized patients, their medical records, their genotyping results and the ability to call these patients back for further studies. Access is also provided to over 1.5 million banked pathologic specimens with the ability to access medical records with proper IRB approval. Living patients and pathologic specimens are both searchable by diagnosis and skin diseases are well represented. The Core also offers access to freshly excised healthy human adult skin and neonatal foreskin and to viable populations of purified cells obtained from human skin. Lastly, the core offers immunodeficient NSG mice grafted with human skin and blood. These mice allow study of living human skin in an accessible animal model and are useful for studying topical drug delivery, signaling in living human skin, T cell trafficking to skin, resident memory T cell generation, graft-versus-host disease and skin fibrosis. The Core also provides IRB protocol drafting and support as well as all services necessary for external investigators to utilize these resources. The Research Community potentially consists of any investigator at any institution who wishes to carry out human cell and tissue-based research. We provide scientific projects from 40 investigators who wish to utilize the services of this Core. In summary, the Biobank Core provides access to highly characterized living patients, banked pathologic specimens, fresh human skin and immunodeficient mice engrafted with human skin and blood. The goal of the Biobank Core is to provide access to high quality human tissues to any researcher at any institution with the goal of accelerating human skin disease research.