Clinical Trials Specialist in Developmental Therapeutics

项目摘要 计划的活动描述了一系列的努力，这些努力将建立在我对发育疗法的兴趣上。 和儿童白血病。我将带领一个由医生、研究护士、临床研究协调员组成的团队 HICCC的儿科肿瘤学和发育治疗(DVL)计划，并开发了一系列 临床试验，其中包括NCI赞助的研究。我的目标是增加DVL的应计项目数量 已经很出色的临床试验，通过营销努力扩大，还增加了临床产品组合 在HICCC的试验。我将继续参与儿童肿瘤学小组(COG)的骨髓疾病 委员会和发展治疗委员会。我将在我目前的PI或共同PI中继续努力 公开试验的立场，即COG AAML1921和AAML18P1研究。我将开发一项新的COG研究以 评价一种新的酪氨酸激酶抑制剂在无治疗缓解前剂量降低的方法 患有慢性粒细胞白血病的儿童与初级教员一起工作。此外，我希望找出少数群体收益的障碍。 儿童发展疗法研究中的患者，并制定一项改进计划。 我致力于指导和培训年轻的教师，他们将发展儿科领域的下一代研究 肿瘤学。我将继续努力培训对儿科肿瘤学感兴趣的住院医生和研究员。我会帮助朱尼尔的 教师在HICCC/CUIMC确立自己的角色，并扩大他们在合作中的学术机会 小组和与外部调查人员的合作。

Project Summary The planned activities describe a set of efforts that will build upon my interest in developmental therapeutics and childhood leukemias. I will lead a team of physicians, research nurses, clinical research coordinators in the Pediatric Oncology and Developmental Therapeutics (DVL) Program at the HICCC and develop a portfolio of clinical trials, which includes NCI-sponsored studies. My goal is to increase the number of accruals to the DVL clinical trials, which is already excellent, by expanding with marketing efforts and also grow the portfolio of clinical trials at HICCC. I will continue my involvement in the Children’s Oncology Group (COG) Myeloid Disease Committee and Developmental Therapeutics Committee. I will carry on my efforts in my current PI or co-PI positions for open trials, i.e. the COG AAML1921 and AAML18P1 studies. I will develop a new COG study to evaluate a novel method of dose de-escalation of tyrosine kinase inhibitors before treatment-free remission in children with CML working with a junior faculty. In addition, I hope to identify barriers to the accrual of minority patients in pediatric developmental therapeutics studies and institute a plan to improve it. I am devoted to mentoring and training young faculty who will develop next generation research in pediatric oncology. I will continue my efforts to train residents and fellows interested in pediatric oncology. I will help junior faculty to establish their roles at HICCC/CUIMC and also expand their academic opportunities in cooperative groups and collaborations with outside investigators.