Host and parasite factors influencing P. vivax RBC invasion and asexual development

摘要 间日疟原虫威胁着世界上一半的人口，对持续不断的疟疾具有惊人的弹性 消除努力，部分原因是它的独特特性和我们对其生物学的了解很少。在这里，我们 建议使用直接来自柬埔寨的材料进行最先进的转录分析 患者严格评估红细胞多态、宿主免疫和寄生虫因素的重要性 在调节红细胞入侵和间日疟原虫红细胞内发育方面的作用。我们的研究将 不仅可以更好地了解血液的基本分子和细胞过程 使间日疟原虫处于感染阶段，也将为开发更好的疟疾疫苗奠定坚实的基础 重要但未被充分研究的人类病原体。

Abstract Plasmodium vivax threatens half of the world’s population and is surprisingly resilient to on-going malaria elimination efforts, partially due to its unique characteristics and our poor understanding of its biology. Here, we propose to conduct state-of-the-art transcriptomic analyses using materials derived directly from Cambodian patients to rigorously assess the importance of red blood cell polymorphisms, host immunity and parasite factors in modulating the efficacy of red blood cell invasion and P. vivax intraerythrocytic development. Our studies will not only provide a better understanding of the fundamental molecular and cellular processes underlying blood stage P. vivax infections but will also provide a solid foundation to develop better malaria vaccines against this important but understudied human pathogen.