Filtered eyewear to prevent light-induced melatonin suppression while maintaining visual performance and alertness in night-shift working nurses

项目摘要/摘要。 夜间视网膜光线暴露抑制褪黑激素的产生与健康风险有关 上夜班的工人。蓝色遮挡滤光片可以保持夜间褪黑激素水平和单眼光线暴露。 可以从根本上减少夜间褪黑激素的抑制，仅为常规治疗的10% 双目曝光。我们的前提是，在一只眼睛上放置一个蓝色阻挡橙色滤光片将保留 与完全未过滤的视觉相比，在减少光诱导的褪黑素抑制的同时双眼视觉 条件。该解决方案不应妨碍可能需要双目视觉的视觉任务的执行， 它也不应该引起用户的不适。我们建议进行一项实验室实验(目标1)，以确定蓝色- 单独或联合使用滤光片和单眼观察可以有效地在夜间保持褪黑激素。 不影响视觉表现和主观嗜睡(KSS)。目标2将在模拟中进行 西奈山伊坎医学院的教学和研究中心(STAR)，以确定 改变观看干预可能会影响褪黑激素水平和需要深度的模拟任务表现 医护人员的感知(例如，在假人中插入导管/静脉内插入)。对于目标3，涉及 西奈山医院和纪念馆的夜班工作人员在实际医院环境中工作 在印第安纳州南本德市的一家医院，我们将确定旨在夜间保持褪黑激素的眼镜是否会 要有效、实用，并为社会所接受。目标1将采用交叉主题内设计，曝光 受试者在整个过程中接受6种实验条件(单眼/双眼x过滤/非过滤，2个对照) 共6个独立的会议。目标2将采用受试者内部设计，让受试者接触4个实验 条件(对照、滤过性双眼、滤过性单眼、未滤过性单眼/优势眼遮挡)结束 四次上夜班(间隔至少一周)。目标3将采用类似的受试者内设计 为了在4次为期一周的疗程(每节至少3班)中以唾液褪黑激素水平为目标2， 嗜睡评分和利克特量表反应，作为输出测量。这项建议从实际意义上讲具有重要意义。 因为要测试的方法可以是优雅、廉价、个性化、非侵入性的 保护夜班工人褪黑激素自然合成的光学干预。我们将解决 健康工作设计和幸福感(跨行业)。作为研究实践(R2P)活动的一部分，我们将 用一种新颖但廉价的技术解决夜班护士夜间维持褪黑激素的需要， 并在实践中对其效果进行评价。

Project Summary/Abstract. The suppression of melatonin production by nighttime retinal light exposure has been linked to health risks to nightshift workers. Blue-blocking filters can preserve nighttime melatonin levels, and monocular light exposures can radically reduce nighttime melatonin suppression to as little as 10% of that observed for conventional binocular exposures. Our premise is that positioning a blue-blocking orange filter over one eye will preserve binocular vision while reducing light-induced melatonin suppression relative to a completely unfiltered viewing condition. This solution should not impede the performance of visual tasks that might require binocular vision, nor should it cause user discomfort. We propose a laboratory experiment (Aim 1) to determine whether blue- blocking filters and monocular viewing, alone or in combination, are effective for maintaining melatonin at night without affecting visual performance and subjective sleepiness (KSS). Aim 2 will be conducted at the Simulation Teaching and Research Center (STAR) at the Icahn School of Medicine at Mount Sinai to determine whether altered viewing interventions could influence melatonin levels and simulated task performance requiring depth perception (e.g., catheter / intra venous insertion in dummy) in healthcare workers. For Aim 3, involving nightshift working workers operating in actual hospital environments at Mount Sinai Hospital and Memorial Hospital in South Bend, IN, we will determine whether eyewear aimed at maintaining melatonin at night would be effective, practical, and socially acceptable. Aim 1 will employ a crossover within-subjects design, exposing subjects to 6 experimental conditions (monocular/binocular x filtered/non-filtered, 2 controls) over the course of 6 independent sessions. Aim 2 will employ a within-subjects design exposing subjects to 4 experimental conditions (control, filtered binocular, filtered monocular, unfiltered monocular/dominant eye occluded) over the course of 4 nightshifts (separated by at least a week). Aim 3 will be employ a within-subjects design similar to Aim 2 over the course of 4 one-week sessions (at least 3 shifts per session) with salivary melatonin levels, sleepiness scores, and Likert scale responses, as the output measures. This proposal is significant from a practical perspective because the methods to be tested could serve as elegant, inexpensive, personalized, non-invasive optical interventions to protect the natural synthesis of melatonin in night-shift workers. We will be addressing Healthy Work Design and Well-being (cross-sector). As part of the Research to Practice (r2p) activity, we will address need to maintain melatonin at night among nightshift nurses with a novel, but inexpensive technology, and evaluate its efficacy in practice.