Supporting health equity with bias-free pulse oximetry

通过无偏差脉搏血氧测定法支持健康公平

基本信息

项目摘要

Project Summary Pulse oximeters are essential for physicians’ diagnosis and monitoring of respiratory anomalies in patients. During the COVID-19 pandemic, their importance has grown because pulse-oximeter measurements of hypoxemia have become the major indication for hospitalizing patients. Clinical studies have shown that commercially available pulse oximeter measurements (SpO2) systematically overestimate true arterial oxygen saturation measurements (SaO2) for persons with dark skin pigmentation at low concentrations of O2 in the blood. This bias results in respiratory compromised persons with dark skin not meeting criteria for hospitalization or initiation of ventilator support, thereby putting specific populations (Black, Latinx, and Native American) at disproportionately greater risk for higher mortality or morbidity than those with light skin. No published explanations exist for this well-documented observation and, indeed, the available literature often contrarily states that pulse oximeter measurements are not affected by skin pigmentation. Our theoretical analysis and pilot research, however, demonstrate that the bias is due to present-day devices’ use of red light-emitting diode light sources, whose broad spectral bandwidth interacts with the spectral absorption of melanin concentration in skin to systematically shift the devices’ calibration. This shift causes artificially high values of SpO2 at low blood concentrations of O2 for patients with dark skin. The 3 proposed aims will extend our efforts to date, providing a scientific foundation for eliminating this bias and to foster development and promotion of simple, inexpensive, and bias-free pulse oximeters. In Aim 1, we will: (a) determine if there are other spectrally-dependent constituents in the finger that change with each pulse; (b) determine how light-source bandwidth interacts with melanin, including whether there are other pulse-dependent changes in spectral transmission through the fingers, and how sensitive SpO2 measurements are to light source bandwidth; (c) specify the practical peak wavelength and spectral bandwidth needed for bias-free pulse oximetry; and (d) fabricate an optimized light source that provides bias-free pulse oximeter measurements for testing in Aim 2. In Aim 2, we will demonstrate that the finger probe developed in Aim 1d provides bias-free pulse oximeter measurements (SpO2) that do not overestimate true arterial oxygen saturation measurements (SaO2) for persons with dark skin pigmentation at low blood concentrations of O2. In Aim 3, which will not employ human subjects as in Aims 1 and 2, we will translate our findings (i.e., print, in-person, and social media) to physicians, hospitals, and health care facilities commonly serving underrepresented minority populations. As part of Aim 3, in collaboration with a Stakeholder Board convened by the Institute for Health Equity Research, we will target the medical and affected communities to mitigate the impact of current devices through educational outreach and introduce them to bias-free pulse oximeters once they are available. Finally, we will license the technology to major manufacturers of pulse oximeters, giving preference to those who supply hospitals and clinics serving disadvantaged populations.
项目摘要 脉搏血氧仪对于医生诊断和监测患者的呼吸异常是必不可少的。 在COVID-19大流行期间,由于脉搏血氧仪测量的 低氧血症已成为住院患者的主要指征。临床研究表明 市售脉搏血氧仪测量(SpO 2)系统性地高估了真实动脉氧 在血液中低浓度O2时,对深色皮肤色素沉着的人进行饱和度测量(SaO 2)。 这种偏倚导致呼吸系统受损的深色皮肤患者不符合住院标准, 启动呼吸机支持,从而将特定人群(黑人,拉丁美洲人和美洲原住民)置于 高死亡率或发病率的风险不成比例地高于浅色皮肤的人。没有已发表的 对这一有据可查的观察结果的解释是存在的,事实上,现有的文献往往相反, 指出脉搏血氧仪测量不受皮肤色素沉着的影响。我们的理论分析和 然而,初步研究表明,这种偏见是由于目前的设备使用红色发光二极管 光源,其宽光谱带宽与黑色素浓度的光谱吸收相互作用, 皮肤来系统地改变设备的校准。这种变化导致低血流量时SpO 2值人为升高 对于皮肤黝黑的患者,氧气浓度。这三个拟议目标将延续我们迄今为止的努力, 消除这种偏见的科学基础,并促进开发和推广简单,廉价, 和无偏差脉搏血氧仪。在目标1中,我们将:(a)确定是否存在其他光谱依赖成分 (B)确定光源带宽如何与黑色素相互作用, 包括在通过指状物的光谱透射中是否存在其它脉冲相关的变化,以及 SpO 2测量对光源带宽的敏感程度;(c)指定实际峰值波长,以及 无偏差脉搏血氧测定法所需的光谱带宽;以及(d)制造优化的光源,其提供 Aim 2中用于测试的无偏差脉搏血氧仪测量。在目标2中,我们将证明手指探头 Aim 1d中开发的无偏倚脉搏血氧仪测量(SpO 2)不会高估真实 动脉血氧饱和度测量(SaO 2)的人与深色皮肤色素沉着在低血 O2的浓度。目标3不像目标1和目标2那样使用人类受试者,我们将把我们的 发现(即,印刷品、面对面和社交媒体),通常提供给医生、医院和医疗机构, 为代表性不足的少数民族服务。作为目标3的一部分,与利益攸关方委员会合作 由健康公平研究所召集,我们将针对医疗和受影响的社区, 通过教育推广减轻当前设备的影响,并向其介绍无偏置脉冲 血氧饱和度仪一旦可用。最后,我们将把这项技术授权给脉冲的主要制造商 血氧计,优先考虑那些为弱势群体提供医院和诊所的供应商。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Mariana Gross Figueiro其他文献

Mariana Gross Figueiro的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Mariana Gross Figueiro', 18)}}的其他基金

Filtered eyewear to prevent light-induced melatonin suppression while maintaining visual performance and alertness in night-shift working nurses
过滤眼镜可防止光引起的褪黑激素抑制,同时保持夜班护士的视觉表现和警觉性
  • 批准号:
    10639722
  • 财政年份:
    2023
  • 资助金额:
    $ 79.47万
  • 项目类别:
Supporting health equity with bias-free pulse oximetry
通过无偏差脉搏血氧测定法支持健康公平
  • 批准号:
    10701873
  • 财政年份:
    2022
  • 资助金额:
    $ 79.47万
  • 项目类别:
Studying 24-hour rhythms of light exposure, alignment with rest-activity cycle, and cardiometabolic health in a nationally representative sample
在全国代表性样本中研究 24 小时光照节律、与休息活动周期的一致性以及心脏代谢健康
  • 批准号:
    10516569
  • 财政年份:
    2022
  • 资助金额:
    $ 79.47万
  • 项目类别:
Studying 24-hour rhythms of light exposure, alignment with rest-activity cycle, and cardiometabolic health in a nationally representative sample
在全国代表性样本中研究 24 小时光照节律、与休息活动周期的一致性以及心脏代谢健康
  • 批准号:
    10668466
  • 财政年份:
    2022
  • 资助金额:
    $ 79.47万
  • 项目类别:
Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation
系统性光照对接受自体干细胞移植的多发性骨髓瘤患者的昼夜节律拖累、炎症、中性粒细胞减少性发热和症状负担的影响
  • 批准号:
    10392164
  • 财政年份:
    2022
  • 资助金额:
    $ 79.47万
  • 项目类别:
Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation
系统性光照对接受自体干细胞移植的多发性骨髓瘤患者的昼夜节律拖累、炎症、中性粒细胞减少性发热和症状负担的影响
  • 批准号:
    10670054
  • 财政年份:
    2022
  • 资助金额:
    $ 79.47万
  • 项目类别:
Clock modulation in circadian desynchrony induced diabetes and atherovascular disease - mechanisms and interventions
昼夜节律不同步引起的糖尿病和动脉粥样硬化疾病的时钟调节 - 机制和干预措施
  • 批准号:
    10454373
  • 财政年份:
    2021
  • 资助金额:
    $ 79.47万
  • 项目类别:
Methodology Issues in a Tailored Light Treatment for Persons with Dementia
为痴呆症患者量身定制光疗的方法学问题
  • 批准号:
    10320581
  • 财政年份:
    2021
  • 资助金额:
    $ 79.47万
  • 项目类别:
Methodology Issues in a Tailored Light Treatment for Persons with Dementia
为痴呆症患者量身定制光疗的方法学问题
  • 批准号:
    10570263
  • 财政年份:
    2021
  • 资助金额:
    $ 79.47万
  • 项目类别:
Clock modulation in circadian desynchrony induced diabetes and atherovascular disease - mechanisms and interventions
昼夜节律不同步引起的糖尿病和动脉粥样硬化疾病的时钟调节 - 机制和干预措施
  • 批准号:
    10622428
  • 财政年份:
    2021
  • 资助金额:
    $ 79.47万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 79.47万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 79.47万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 79.47万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 79.47万
  • 项目类别:
    Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 79.47万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 79.47万
  • 项目类别:
    Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 79.47万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 79.47万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 79.47万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 79.47万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了