Studying 24-hour rhythms of light exposure, alignment with rest-activity cycle, and cardiometabolic health in a nationally representative sample
在全国代表性样本中研究 24 小时光照节律、与休息活动周期的一致性以及心脏代谢健康
基本信息
- 批准号:10668466
- 负责人:
- 金额:$ 11.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-20 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:Activity CyclesAdultAdverse effectsBehaviorBehavioralBiological MarkersBlood PressureBody CompositionCardiometabolic DiseaseCardiovascular DiseasesCharacteristicsCircadian RhythmsCircadian desynchronyClinicalDarknessDataData AnalysesDevelopmentDiabetes MellitusDiseaseDisparityDisparity populationElementsEnvironmental ExposureExerciseExposure toGeneral PopulationHealthHourHumanImpairmentInvestigationLightLinkLipidsLow Income PopulationMeasurementMeasuresMetabolic DiseasesMethodsNational Health and Nutrition Examination SurveyObesityOccupationalOutcomeParticipantPatient Self-ReportPatternPeriodicityPhasePhysiologicalPilot ProjectsPlayPopulationProcessPublic HealthPublishingReportingRestRisk FactorsRoleSamplingScheduleSignal TransductionSleepStimulusSubgroupSystemTestingTherapeutic InterventionUnderrepresented PopulationsVariantWristactigraphycardiometabolic riskcardiometabolismcircadiandesigndisease disparitydisorder riskethnic minorityglycemic controlhealth disparityimprovedinsightlight entrainmentmodifiable riskmolecular clockneighborhood disadvantagenovelolder menpreventive interventionracial minorityshift worksleep healthsocioeconomicsstudy characteristicssuprachiasmatic nucleustherapy development
项目摘要
PROJECT SUMMARY
Circadian rhythms, generated by endogenous molecular clocks and entrained by the light-dark cycle, play a
central role in orchestrating many physiological and behavioral processes related to cardiometabolic health. A
growing body of evidence has linked light exposure at different times of the day and cardiometabolic outcomes,
suggesting that characteristics of 24-hour light-dark cycle may be unique predictors of disease risk. However,
there is a lack of investigation focusing on comprehensively assessing 24-hour light exposure, and in particular,
its alignment with diurnal behavioral, to understand its health implications in human populations. A well-
established hallmark of a healthy circadian timing system is the synchronization and proper alignment of multiple
elements, such as between the environmental stimuli (e.g., light-dark cycle) and diurnal behaviors (e.g., activity-
rest cycle). Our pilot study in older men applied phasor analysis to assess the alighnment between actigraphy-
measured 24-hour light-dark and activity-rest cycles, and we found that impaired alignment between the two was
associated with diabetes. These findings suggest that poor synchronization between the timing of light exposure
and activity patterns may be a unique predictor of cardiometabolic risk, a novel hypothesis that needs to be
tested in broader populations. We propose to test this hypothesis by conducting secondary data analysis in the
National Health and Nutrition Examination Survey (NHANES, 2011-2014), which has detailed data on 24-hour
light and activity patterns and rich information on cardiometabolic health. Moreover, the diverse and nationally
representative sample will allow us to determine how 24-hour patterns of light exposure, its interrelationship with
activity-rest cycles, and their associations with cardiometabolic outcomes may vary among subgroups with
different demographic, socioeconomic, and occupational characteristics. Aim 1 Study characteristics of 24-
hour light exposure and its alignment with rest and activity patterns in relation to cardiometabolic health
in adult participants in NHANES. In this aim we will apply parametric and nonparametric methods to
characterize multiple aspects of light-dark cycles and phasor analysis to characterize the alignment between
light-dark and activity-rest cycles to study their associations with cardiometabolic outcomes. Aim 2 Study light
exposure, alignment with rest and activity, and their associations with cardiometabolic health in adult
populations with different demographic, socioeconomic and occupational attributes. In this aim we will
examine multiple population attributes as determinants of 24-hour light-dark cycles and its alignment with activity-
rest cycles, and as moderators of the association between light exposure and cardiometabolic health. Light
exposure is a potentially modifiable risk factor for cardiometabolic diseases, and our study will help better
understand the contribution of light exposure to cardiometabolic health and disease disparities, and provide
evidence for developing preventive and therapeutic interventions aimed at manipulating light exposure and
activity-rest patterns to improve circadian function and cardiometabolic health.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mariana Gross Figueiro其他文献
Mariana Gross Figueiro的其他文献
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{{ truncateString('Mariana Gross Figueiro', 18)}}的其他基金
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过滤眼镜可防止光引起的褪黑激素抑制,同时保持夜班护士的视觉表现和警觉性
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10639722 - 财政年份:2023
- 资助金额:
$ 11.98万 - 项目类别:
Supporting health equity with bias-free pulse oximetry
通过无偏差脉搏血氧测定法支持健康公平
- 批准号:
10701873 - 财政年份:2022
- 资助金额:
$ 11.98万 - 项目类别:
Studying 24-hour rhythms of light exposure, alignment with rest-activity cycle, and cardiometabolic health in a nationally representative sample
在全国代表性样本中研究 24 小时光照节律、与休息活动周期的一致性以及心脏代谢健康
- 批准号:
10516569 - 财政年份:2022
- 资助金额:
$ 11.98万 - 项目类别:
Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation
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10392164 - 财政年份:2022
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$ 11.98万 - 项目类别:
Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation
系统性光照对接受自体干细胞移植的多发性骨髓瘤患者的昼夜节律拖累、炎症、中性粒细胞减少性发热和症状负担的影响
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10670054 - 财政年份:2022
- 资助金额:
$ 11.98万 - 项目类别:
Supporting health equity with bias-free pulse oximetry
通过无偏差脉搏血氧测定法支持健康公平
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- 资助金额:
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为痴呆症患者量身定制光疗的方法学问题
- 批准号:
10320581 - 财政年份:2021
- 资助金额:
$ 11.98万 - 项目类别:
Methodology Issues in a Tailored Light Treatment for Persons with Dementia
为痴呆症患者量身定制光疗的方法学问题
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10570263 - 财政年份:2021
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Clock modulation in circadian desynchrony induced diabetes and atherovascular disease - mechanisms and interventions
昼夜节律不同步引起的糖尿病和动脉粥样硬化疾病的时钟调节 - 机制和干预措施
- 批准号:
10622428 - 财政年份:2021
- 资助金额:
$ 11.98万 - 项目类别:
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