CACHET - IHSFC

1.综合健康科学设施核心：摘要 综合卫生科学设施核心(IHSFC)将提供基础设施和高度集中的交通 向荣誉成员提供纪律服务，包括接触队列和生物银行；环境卫生 科学(EHS)设计、实施和翻译研究服务；创新人口方法 使用包括设备、传感器和可穿戴设备在内的传统和尖端技术进行暴露评估 和移动应用程序技术；以及新的统计服务，重点是地理空间建模方面的挑战 以及混合物的评价。这一系列服务将提供工具，将基础研究转化为 支持疾病预防和缓解种族/民族环境健康差距的知识。 IHSFC将在伊利诺伊大学芝加哥分校(UIC)和芝加哥大学(UofC)都有领导力， 并将在这些机构现有研究资源的基础上，确保核心支持用于 为开展EHS工作开发其他关键资源。IHSFC用于满足以下要求的许多资源 我们两个机构现有的威望调查人员对EHS翻译研究的需求是 两个机构之间的修改、增强、集中和有效组织，通过利用 机构特有的优势和不断增长的核心资源。IHSFC人员包括流行病学专家 研究设计、人口和临床研究、样本收集和质量保证、暴露 支持卓越的风险暴露评估的技术和数据分析，以及相关的统计方法 现代环境健康研究。IHSFC人员将与环境部门的人员合作 生物标记物设施核心(EBC)，以满足涉及环境生物标记物的分子分析要求 人体生物材料中的暴露和环境特征。IHSFC还将提供 解释结果并促进将结果传播到芝加哥社区和其他地方 与社区参与核心(CEC)相结合。此外，IHSFC还将与CEC合作 作为相关机构CTSA和癌症中心的核心，翻译基于社区的EHS问题和 关注可能得到威望通过试点项目方案支持的具体科学假设 (PPP)。此外，IHSFC将促进利用人类健康暴露分析资源的项目 (HHEAR)，以进一步提高威望机会，以进行扩大的目标和非目标的分析 与环境相关。

1. INTEGRATED HEALTH SCIENCES FACILITY CORE: ABSTRACT The Integrated Health Sciences Facility Core (IHSFC) will provide infrastructure and highly focused trans- disciplinary services to CACHET members including access to cohorts and bio-banking; environmental health sciences (EHS) design, implementation and translational study services; innovative approaches to population exposure estimation using both traditional and cutting-edge techniques including device, sensors and wearables and mobile app technologies; and novel statistical services with a focus on challenges in geospatial modeling and evaluation of mixtures. This array of services will provide tools to translate fundamental research into knowledge supporting disease prevention and the mitigation of racial/ethnic environmental health disparities. The IHSFC will have leadership at both University of Illinois at Chicago (UIC) and University of Chicago (UofC), and will build upon the existing research resources at these institutions to ensure that Core support is used to develop additional key resources for conducting EHS work. Many of the resources that the IHSFC uses to meet the EHS translational research needs of CACHET investigators that exist at our two institutions have been modified, enhanced, centralized and efficiently organized between the two institutions by leveraging the institution-specific strengths and growing Core resources. IHSFC personnel include experts in epidemiological study design, population and clinic-based studies, specimen collection and quality assurance, exposure technology and data analytics to support superior exposure assessment, and statistical methods relevant for modern environmental health studies. IHSFC personnel will collaborate with personnel in the Environmental Biomarkers Facility Core (EBC) to address molecular assay requirements involving biomarkers of environmental exposures and environmental signatures in human biological materials. The IHSFC will also provide interpretation of results and facilitate dissemination of the results to Chicago communities and beyond in conjunction with the Community Engagement Core (CEC). In addition, the IHSFC will work with the CEC as well as relevant Institutional CTSA and Cancer Center Cores to translate community-based EHS questions and concerns into specific scientific hypotheses that may be supported by CACHET through the Pilot Project Program (PPP). Furthermore, the IHSFC will facilitate projects that utilize the Human Health Exposure Analysis Resource (HHEAR), to further enhance CACHET opportunities to conduct expanded target and untargeted analyses of environmental relevance.