Methods for Selective Organic Synthesis based on Ionic Catalysts

项目摘要 该研究计划的主要目标是开发催化对映选择性 基于过渡金属和手性阴离子催化的转化将被广泛应用于 适用于制备治疗相关的有机分子。为实现这一 最后，对C-O，C-N和C-卤素的不对称选择性构建的新反应 债券被提议。特别强调的是发展的方法， 氟和含氟官能团的选择性引入。 此外，产生或使用可用的结构单元的反应，例如 烯烃和硼酸将成为目标。这些方法将利用新的催化剂 基于金（III）络合物和基于磷酸的手性阴离子的平台， 氟化结构单元和杂环的构建 将研究这些反应的机械基础，重点是 揭示非共价相互作用在实现选择性方面的作用。因此我们 预计该计划将为合成化学家和生物医学研究人员提供 使用额外的工具（反应、催化剂、配体等）用于分子合成， 单一对映体构建，并为进一步开发提供原则 和应用

Project Summary The major goal of this research program is to develop catalytic enantioselective transformations based on transition metal and chiral anion catalysis that will be broadly applicable to the preparation of therapeutically relevant organic molecules. Towards this end, new reactions for the enantioselective construction of C-O, C-N and C-halogen bonds are proposed. Particular emphasis is placed on the development of methods for the selective introduction of fluorine and fluorine-containing functional groups. Additionally, reactions that generate or employ available building blocks, such as alkenes and boronic acids, will be targeted. These methods will leverage new catalyst platforms, based on gold(III) complexes and phosphoric acid-based chiral anions, for the construction of fluorinated building blocks and heterocycles Additionally, the mechanistic underpinnings of these reactions will be studied, with a focus on uncovering the role of non-covalent interactions in achieving selectivity. Thus, we anticipate that this program will provide synthetic chemists and biomedical researchers with additional tools (reactions, catalysts, ligands etc.) for molecular synthesis and for single enantiomer construction, as well as provide principles for further development and application.