Development of a novel polysubstance assessment tool for vulnerable subpopulations

项目总结/摘要 本次及时且重要的K 01旨在为PI（Bunting博士）提供培训和专业知识 有必要成为一个独立的物质使用研究的调查员，专门从事开发 改善弱势群体健康结果的干预措施，特别侧重于多种物质 使用阿片类药物。尽管多种药物使用的普遍性及其与高风险结局的相关性 例如过量，但我们认识上仍然存在重大差距，部分原因是现有物质的局限性 使用筛选和评估工具。准确测量高风险人群中多种药物使用的能力 是制定有效战略改善与药物有关的健康的关键一步 这个人口的结果。该提案的总体目标是开发一种新型多物质 评估工具和识别的相关因素和动机的多物质使用行为之间的高， 易受伤害的人群。这一系列调查的长期目标是制定有针对性的干预措施， 作为一名独立的物质使用调查者， research.为了实现这一目标，拟议的奖励旨在加强PI的现有培训， 社会学和保健服务，使她能够：（1）获得方法学 仪器开发和验证的特定技能，（2）提高她独立进行 研究，包括招募和保留弱势群体以及远程研究管理，以及 (3)发展针对弱势群体的保健服务干预发展的重点技能（即， 使用药物的人，涉及正义）。这些技能将在高影响力的培训中得到发展 环境的纽约大学格罗斯曼医学院与协作指导团队， 全国知名专家。培训计划在战略上得到严格的混合方法的补充 study.建立在以前的培训，同时扩大到新的技能，研究的独立线旨在：（1） 开发和测试一种新的评估工具的心理测量特性，以测量多物质的使用， 高危弱势人群，（2）检查新型多种物质使用评估的预测有效性 工具，通过检查高风险脆弱人群6个月内的风险行为，以及（3）获得 关于多种物质使用干预战略的制定和可接受性的初步数据 人口。到该奖项结束时，PI将被定位为多物质使用领域的新兴领导者 研究并定位于通过未来的R-机制在多物质使用干预的职业生涯中脱颖而出 融资机会。

PROJECT SUMMARY/ ABSTRACT The purpose of this timely and significant K01 is to provide the PI (Dr. Bunting) with the training and expertise necessary to become an independent investigator of substance use research, specializing in the development of interventions that improve health outcomes of vulnerable populations with a specific focus on polysubstance use involving opioids. Despite the prevalence of polysubstance use and its association with high-risk outcomes such as overdose, significant gaps in our understanding persist in part due to limitations of existing substance use screening and assessment tools. The ability to accurately measure polysubstance use among high-risk populations is a critical step towards developing effective strategies for improving substance-related health outcomes of this population. The overall goal of the proposal is the development of a novel polysubstance assessment tool and identification of correlates and motivations of polysubstance use behaviors among high- risk vulnerable populations. The long-term goal of this line of investigation is to develop interventions targeted to polysubstance use behaviors in vulnerable populations as an independent investigator of substance use research. To achieve this goal, the proposed award has been designed to augment the PI’s existing training in sociology and health services through a comprehensive plan that will enable her to: (1) obtain methodological skills specific to instrument development and validation, (2) enhance her ability to conduct independent research including the recruitment and retention of vulnerable populations and remote study management, and (3) develop focused skills in health services intervention development specific to vulnerable populations (i.e., persons who use substances, justice-involved). These skills will be developed at the high-impact training environment of the New York University Grossman School of Medicine with a collaborative mentoring team of nationally renowned experts. The training plan is strategically complemented by a rigorous mixed-method study. Building on prior training while expanding to new skills, the independent line of research aims to: (1) develop and test the psychometric properties of a novel assessment tool to measure polysubstance use for high-risk vulnerable populations, (2) examine the predictive validity of the novel polysubstance use assessment tool by examining risk behaviors over a 6-month period in a high-risk vulnerable population, and (3) acquire preliminary data regarding the development and acceptability of intervention strategies for polysubstance use populations. By the conclusion of this award, the PI will be positioned as a rising leader in polysubstance use research and positioned to excel in a career of polysubstance use interventions through future R-mechanism funding opportunities.