Administrative Core

项目概要/摘要-行政核心 人工智能驱动的结构化抗病毒平台（ASAP）AViDD中心是一个分布式的组织， 抗病毒药物的发现工作，将产生-除了三个研究性新药（IND）申请- 强大的开放科学数据和试剂管道，使全球基于结构的抗病毒药物发现成为可能。 研究项目被组织为支持结构的发现管道的顺序阶段， 通过科学核心，项目之间协调良好，对快速发展至关重要， 探索计划行政核心的目标是协调和支持这些活动， 高效执行研究项目，协调发现项目的战略性及时移交 在项目之间，随着活动在发现管道的连续阶段中的进展， 执行支持这些努力的科学核心，并协助迅速传播所有科学核心， 向全球抗病毒药物发现社区输出。行政核心领导反映了整体ASAP AViDD中心领导层，由三名具有有效协作记录的调查员组成 COVID Moonshot项目的研究人员成功地提供了SARS-CoV-2口服抗病毒药物Mpro 在18个月内进入临床前研究：核心负责人John Chodera（MSKCC），co-I Alpha Lee（PostEra）和co-I 本佩里（DNDi），每个监督一个子集的活动。一位经验丰富的行政主管将 监督ASAP的日常运作、财务状况和中心内的科学交流， NIAID和外部;项目协调员将处理委托的操作任务，会议协调， 分包管理和监督合同研究组织（CRO）。发展项目 将建立一个奖励计划，使新技术能够迅速融入中心项目，或 深入研究新的耐药性强大的目标疾病生物学，以及指导项目奖励计划 将能够招募跨学科的科学家到抗病毒发现领域。一个五人 将招募科学顾问委员会（SAB），积极参加中心季度会议， 为进行/不进行决策提供关键输入，以便将发现活动推广到后续项目， 提供关于中心进度的反馈，并选择发展和指导项目获奖者。的 行政核心将确保所有中心的运作是公开和透明的，坚持我们的核心开放 加速全球抗病毒药物发现的科学哲学。

PROJECT SUMMARY / ABSTRACT - Administrative Core The AI-driven Structure-enabled Antiviral Platform (ASAP) AViDD Center is organized as a distributed antiviral discovery effort that will produce---in addition to three Investigational New Drug (IND) applications---a robust pipeline of open science data and reagents to enable global structure-based antiviral drug discovery. Research Projects are organized as the sequential stages of a structure-enabled discovery pipeline, supported by Scientific Cores, with well-coordinated handoffs between Projects essential to rapid progression of discovery programs. The goal of the Administrative Core is to coordinate and support these activities, aid efficient execution of Research Projects, coordinate strategic and timely handoff of discovery programs between Projects as campaigns progress through sequential stages of the discovery pipeline, oversee efficient execution of Scientific Cores supporting these efforts, and assist in the rapid dissemination of all scientific output to the global antiviral discovery community. Administrative Core leadership mirrors the overall ASAP AViDD Center Leadership, consisting of three investigators with a track record of effective collaboration as core investigators of the COVID Moonshot project that succeeded in delivering a SARS-CoV-2 oral Mpro antiviral into preclinical studies in 18 months: Core Lead John Chodera (MSKCC), co-I Alpha Lee (PostEra), and co-I Ben Perry (DNDi), each overseeing a subset of activities. An experienced Administrative Director will oversee the day-to-day operations of ASAP, its finances, and scientific communications within the center, with NIAID, and externally; a Project Coordinator will handle delegated operations tasks, meeting coordination, subaward management, and overseeing contract research organizations (CROs). A Developmental Project award program will be established to enable new technologies to rapidly be integrated into Center Projects or in-depth investigation of new resistance-robust target disease biology, and a Mentored Project award program will enable the recruitment of interdisciplinary scientists to the field of antiviral discovery. A five-member Scientific Advisory Board (SAB) will be recruited that will actively participate in Center Quarterly meetings, provide critical input into go/no-go decisions for promoting discovery campaigns to subsequent projects, provide feedback on Center progress, and select Developmental and Mentored Project Awardees. The Administrative Core will ensure that all Center operations are open and transparent, adherent to our core open science philosophy for accelerating global antiviral discovery.