University of New Mexico Cancer Center Support Grant

总体构成部分：新墨西哥州综合癌症中心 项目总结/摘要 自2005年被指定为NCI癌症中心和2015年被指定为NCI综合癌症中心以来， 新墨西哥州大学综合癌症中心（UNMCCC）及其合作伙伴Lovelace 生物医学/洛夫莱斯呼吸研究所（LRRI），已经建立了一个单一的跨学科癌症- 在其集水区，新墨西哥州（NM）的重点研究企业。述区分 联合国儿童基金会的特点包括：1）它所服务的多民族、城市/农村人口-主要是 西班牙裔/拉丁裔、非西班牙裔白色、美洲印第安人和黑人-癌症模式截然不同 发病率和死亡率，巨大的癌症健康差距，以及深刻的社会经济脆弱性; 2） 与美国印第安人（AI）的深入参与和独特的研究，教育和培训伙伴关系 国家和西班牙裔（H）社区; 3）全州范围的癌症监测，筛查登记，和独特的远程监测， 指导基础设施，促进癌症控制研究;和4）全州范围的临床试验网络，资助 作为少数民族/服务不足的NCI社区肿瘤学研究计划，吸引了该州大多数 肿瘤提供者。UNMCCC的使命是减少癌症负担，战胜巨大的癌症。 通过突破性的跨学科研究，翻译的NM集水区的健康差距， 临床和社区干预的发现，有影响力的双向社区参与， 更多样化的癌症工作人员，以及提供卓越的癌症护理。通过广泛的战略规划和 评估，UNMCCC显着重组和加强其领导，3研究计划，9 共享资源和临床研究基础设施，以确保中心的持续增长。2015年以来，33 招募了新成员，并设立了23个捐赠职位。该中心的102名成员聚集在 3个跨学科的，高度转化的研究项目（癌症控制与人口科学，细胞与 分子肿瘤学和癌症治疗学），由36，196，038美元的年度直接癌症相关 资金，其中27，542，340美元是同行评审，8，245，544美元是NCI。加上3，009，657美元的额外NCI 合同和补充，每年NCI对中心的资助总额为11，255，201美元。联合国儿童基金会的研究高度 互动和有影响力（合作出版物在其研究计划中占34-60%， 在高影响力期刊上发表了930篇论文，申请了136项专利，成立了10家新公司。4个联合国儿童基金会 这些发现被转化为早期试验，其中之一现在是国家NCTN NRG试验。在1361年 在2019年的应计费用中，40%的介入治疗应计费用是少数种族/族裔（29% H; 6% AI）， 55%的干预性非治疗应计费用（33% H; 12% AI）。在530名受训人员中，72%为少数族裔/多种族裔 学者随着27个合作赠款的授予（包括NCI参与者参与癌症基因组 测序研究中心和3个专注于环境暴露和癌症因果关系， 部落民族），联合国儿童基金会将继续对其集水区和国家产生深远的影响。

OVERALL COMPONENT: THE UNIVERSITY OF NEW MEXICO COMPREHENSIVE CANCER CENTER PROJECT SUMMARY / ABSTRACT Since achieving designation as a NCI Cancer Center in 2005 and a NCI Comprehensive Cancer Center in 2015, the University of New Mexico Comprehensive Cancer Center (UNMCCC) and its Consortium Partner, Lovelace Biomedical/The Lovelace Respiratory Research Institute (LRRI), have built a single transdisciplinary cancer- focused research enterprise across its catchment area, the State of New Mexico (NM). The distinguishing characteristics of the UNMCCC include: 1) the multiethnic, urban/rural populations that it serves - primarily Hispanic/Latino, non-Hispanic White, American Indian, and Black - with strikingly different patterns of cancer incidence and mortality, tremendous cancer health disparities, and profound socioeconomic vulnerabilities; 2) deep engagement and unique research and education and training partnerships with American Indian (AI) Nations and Hispanic (H) communities; 3) statewide cancer surveillance, screening registries, and unique tele- mentoring infrastructures that facilitate cancer control research; and 4) a statewide clinical trials network, funded as a Minority/Underserved NCI Community Oncology Research Program, engaging the majority of the state's oncology providers. The UNMCCC mission is to reduce the cancer burden and overcome the tremendous cancer health disparities of the NM catchment area through ground-breaking transdisciplinary research, translation of discoveries to clinical and community interventions, impactful bi-directional community engagement, training of a more diverse cancer workforce, and delivery of exceptional cancer care. With extensive strategic planning and evaluation, the UNMCCC significantly restructured and enhanced its Leadership, 3 Research Programs, 9 Shared Resources, and clinical research infrastructure to assure the Center's continued growth. Since 2015, 33 new Members were recruited and 23 Endowed Positions created. The Center's 102 Members are clustered into 3 interdisciplinary, highly translational Research Programs (Cancer Control & Population Sciences, Cellular & Molecular Oncology, and Cancer Therapeutics), supported by $36,196,038 in annual direct cancer-relevant funding, of which $27,542,340 is peer-reviewed and $8,245,544 is NCI. With $3,009,657 in additional NCI contracts and supplements, total annual NCI funding to the Center is $11,255,201. UNMCCC research is highly interactive and impactful (with collaborative publications ranging from 34-60% in its Research Programs, 16% of 930 publications in high impact journals, 136 patents filed, and 10 new companies launched). Four UNMCCC discoveries were translated to early phase trials, one of which is now a national NCTN NRG trial. Of 1361 accruals in 2019, 40% of interventional treatment accruals were racial/ethnic minorities (29% H; 6% AI), as were 55% of interventional non-treatment accruals (33% H; 12% AI). Among 530 trainees, 72% were minority/diverse scholars. With the awarding of 27 collaborative grants (including a NCI Participant Engagement-Cancer Genome Sequencing Research Center and 3 focused on environmental exposure and cancer causation, all engaging Tribal Nations), the UNMCCC will continue to have a profound impact on its catchment area and the nation.