Pelvic Floor Disorders Network Clinical Site

项目摘要 这个应用程序是一个骨盆底疾病网络临床网站包含两个创新的 随机对照试验和全面描述西北医学的独特 作为一个团队和环境，我们的优势是为所有PFDN试验做出贡献。我们的概念提案借鉴了 我们团队在运动生理学、围手术期优化和术后恢复方面的集体经验。 该提案描述了一项关于脱垂手术后处方性早期锻炼的随机对照试验， 减少失调并改善恢复，而不会对骨盆底结果产生任何负面影响。我们 拟议的研究将超越现有的研究，是第一个实施和定量 评估（使用加速计数据）术后锻炼方案及其对恢复的影响， 盆底症状。此外，我们的建议突出了我们的大，高容量，多， 学科团队，该团队来自多个地区医院的不同患者人群，以确保 PFDN临床试验的公平性和包容性。我们还可以利用我们的资源和合作， 两个NIDDK合作网络有关尿失禁和膀胱健康，以推进PFDN的 目标. NM团队是一个全国公认的协作，生产和建立的团体。 调查人员准备好领导设计，执行，分析和传播这一 多中心RCT以及参与和领导PFDN内的其他研究。

Project Abstract This application to be a Pelvic Floor Disorders Network Clinical Site contains both an innovative randomized controlled trial and comprehensive description of Northwestern Medicine’s unique strengths, as a team and environment, to contribute to all PFDN trials. Our concept proposal draws on the collective experience of our team in exercise physiology, perioperative optimization, and postoperative recovery. The proposal describes a randomized controlled trial of prescriptive early exercise following prolapse surgery to reduce deconditioning and improve recovery without any negative impact on pelvic floor outcomes. Our proposed study will go beyond existent research and be the first to implement and quantitatively evaluate (using accelerometer data) a postoperative exercise regimen and its effects on recovery and pelvic floor symptoms. In addition, our proposal highlights the strengths of our large, high volume, multi- disciplinary team, which draws from a diverse patient population across several regional hospitals to ensure equity and inclusion within PFDN clinical trials. We can also leverage our resources and collaborations as part of two NIDDK cooperative networks related to urinary incontinence and bladder health to advance the PFDN’s goals. The NM team is a nationally recognized group of collaborative, productive, and established investigators well poised to lead the design, implementation, analysis and dissemination of this multicenter RCT as well as participate in and lead additional studies within the PFDN.