Undergraduate Research Experiences in Neurogenetics and Neurogenomics

该计划旨在为10名本科生提供神经遗传学和神经基因组学下一代测序（NGS）分析的暑期研究经验。NGS已经改变了基因组学领域，并越来越多地渗透到生物科学研究和医学的各个方面。利用NGS来了解大脑和神经系统疾病是生物医学科学的主要前沿之一，并将在不久的将来和未来几十年推动该领域的进步。在神经科学领域，对具有强大的基因组学相关数据分析技能的研究人员将有巨大的需求。这种需求在生物科学研究生课程以及生物医学专业学校对定量分析技能的日益重视中是显而易见的。为了满足这一需求，我们将建立一个名为“神经遗传学和神经基因组学基因组学中的熊（BIG-NGG）”的项目。它将利用由加州大学洛杉矶分校定量与计算生物科学研究所（QCB）和QCB合作实验室支持的现有暑期项目“基因组学中的熊（BIG-Summer）”的基础设施。BIG - Summer包括注重NGS数据分析技能的实践研讨会教程，以及基因组学的动手研究经验。拟议的R25计划将允许另外10名学生参加BIG，特别是学习神经遗传学和神经基因组学不断发展的前沿研究领域。学生将是进入大三和大四的定量或生物科学专业的学生。我们希望我们的许多参与者将有这个研究经验，作为继续生物医学研究的起点，无论是定量生物科学博士项目，如生物信息学博士项目或神经科学博士项目。

The proposed program is to provide a summer research experience in next generation sequencing (NGS) analysis for neurogenetics and neurogenomics for 10 undergraduate students. NGS has transformed the field of genomics and is increasingly permeating all aspects of biosciences research and medicine. Using NGS to understand the brain and neurological disease is one of the major frontiers in biomedical science and will drive advances in the field in the near future and for decades to come. There will be a huge need for researchers in neuroscience with strong data analysis skills relevant to genomics. This need is evident in the increasing emphasis on quantitative analysis skills in biosciences graduate programs as well as in biomedical professional schools. To address this need, we will establish the program called “Bruins in Genomics in Neurogenetics and Neurogenomics (BIG­NGG)”. It will leverage the infrastructure of an existing summer program “Bruins in Genomics (BIG­Summer)”, supported by the Institute for Quantitative and Computational Biosciences (QCB) at UCLA, and the QCB Collaboratory. BIG­ Summer consists of a combination of practical workshop tutorials that focus on NGS data analysis skills, and a hands-on research experience in genomics. The proposed R25 program will allow 10 additional students to participate in BIG, and specifically to learn about the growing and cutting-edge research field of neurogenetics and neurogenomics. The students will be quantitative or biosciences majors entering their junior and senior years. We expect that many of our participants will have this research experience serve as a launching point for continuing in biomedical research in either quantitative biosciences Ph.D. programs such as a Bioinformatics Ph.D. program or a Neuroscience Ph.D. program.