South Texas Alzheimer's Disease Center Imaging Core

成像核心(IC)突出了南得克萨斯州阿尔茨海默病中心(STAC)的优势，该中心 拥有大量的基础设施、成像专业知识和培训计划。它由研究组成 影像研究所(RII)，放射学系和放射科学研究生计划 (RSGP)。RII是一个支持南得克萨斯州生物医学研究30年的研究单位， 包括众多的国际合作。Pi Fox有&gt；100种出版物/与Genetics的多次赠款 和UTRGV的多重组学核心PI，Blangero。RII与临床核心大楼位于同一大楼内 (CC)和UTHSA的人群神经科学核心，包括：磁共振成像和 人(3-T)和动物(7-T，12-T)的光谱学(MR/MRSI)；正电子发射断层扫描(PET) 人和动物；用于PET同位素生产的两台医用回旋加速器；以及放射性药物生产 设施，包括FDA批准的(ANDA&IND)cGMP商业化生产设施。辅助功能 包括扫描仪内性能控制系统(刺激传递和响应记录)；图像引导， 机器人经颅磁刺激(IrTMS)。RII教师提供图像获取方面的专业知识(包括 放射化学和脉冲序列编辑)、图像预处理和复杂分析，包括 机器学习，人工智能。映像归档、分析和共享(XNAT)功能由虚拟 计算机，新的现场高性能计算集群(GENIE)，并随时可以访问德克萨斯州 先进计算中心。放射科提供神经放射学专业知识(包括 专门用于研究的透视套件)以及另外两台3T磁共振成像和一台PET/CT扫描仪，也在同一 作为CC的建筑。STAC是几个临床试验的站点(AHEAD 3-45，markVCID，GOBS，TARCC) 证明有能力获得高质量的MRI(包括DTI、CVR、fcMRI)、淀粉样蛋白、tau和FDG PET。我们 作为临床护理的一部分，定期获得ADNI-3方案MRI，并已在5个MRI中实施该方案 扫描仪(UTHSA 3台，拉雷多和哈林根CC站点各1台)。我们会拿到所有人的核磁共振扫描 CC参与者，每年，还将获得淀粉样蛋白(PIB)和tau(T807，fltaucipir)PET进行分类 使用A/T/N标准的参与者。我们招募了一名神经放射学家、放射化学家和计算分析员 在过去的一年。我们已经实施了尸检全脑MRI方案(以神经病理学为核心)。集成电路 学院在多模式核磁共振、功能核磁共振以及应用和开发新的图像分析方面处于领先地位 回答与ADRD相关的问题的方法；他们在以下方面领导MRI协调/分析 冲锋，iShare财团和冲刺思维。RSGP通过监督3个项目支持STAC REC 由IC核心领导者指导的博士学位课程：神经科学成像(P.Fox)、人类成像(G. Clarke)和诊断放射学(M.Habes)以及R25医学科学家培训计划的合作伙伴 (MSTP，PI Cavazos，他也是STAC REC的负责人)培训医学/博士科学家。

The Imaging Core (IC) highlights the strengths of the South Texas Alzheimer Center (STAC), which has a critical mass of infrastructure, imaging expertise, and training programs. It is comprised of the Research Imaging Institute (RII), the Department of Radiology and the Radiological Sciences Graduate Program (RSGP). The RII is a research unit that has supported biomedical research in South Texas for 30 years, including numerous international collaborations. PI Fox has >100 publications/ multiple grants with Genetics and Multiomics core PI, Blangero at UTRGV. The RII is housed in the same building as the Clinical Core (CC) and Population Neuroscience Core at UTHSA and includes: magnetic resonance imaging and spectroscopy (MR/MRSI) for humans (3-T) and animals (7-T, 12-T); positron-emission tomography (PET) for humans and animals; two medical cyclotrons for PET-isotope production; and, radio-pharmaceutical production facilities, including an FDA-approved (ANDA & IND) cGMP commercial-production facility. Ancillary capabilities include in-scanner performance-control systems (stimulus delivery and response recording); image-guided, robotic transcranial magnetic stimulation (irTMS). RII faculty provide expertise in image acquisition (including radiochemistry and pulse-sequence editing), image preprocessing, and sophisticated analysis, including machine learning, AI. Image archiving, analysis and sharing (XNAT) capabilities are provided by virtual computers, a new on-site high-performance compute cluster (GENIE) and ready access to the Texas Advanced Computing Center. The Department of Radiology provides neuroradiologic expertise (including a fluoroscopic suite dedicated to research LP) and 2 additional 3T MRI and a PET/CT scanner, also in the same building as the CC. The STAC is a site for several clinical trials (AHEAD 3-45, markVCID, GOBS, TARCC) demonstrating ability to acquire high quality MRI (with DTI, CVR, fcMRI), amyloid, tau and FDG PET. We routinely obtain ADNI-3 protocol MRI as part of clinical care and have implemented the protocol across 5 MRI scanners (3 at UTHSA and 1 each at Laredo and Harlingen CC sites). We will obtain these MRI scans on all CC enrollees, annually, and will also obtain amyloid (PIB) and tau (T807, flutaucipir) PET to categorize enrollees using A/T/N criteria. We have recruited a neuroradiologist, radiochemist and computational analyst in the past year. We have implemented a post-mortem whole brain MRI protocol (with Neuropathology core). IC faculty are leaders in multimodal MRI, functional MR and in applying and developing novel image analysis methods to answer questions relevant to ADRD; they are leading MRI harmonization/analyses within CHARGE, iSHARE consortia and in SPRINT-MIND. The RSGP supports the STAC REC by overseeing 3 doctoral degree programs directed by IC core leaders: Neuroscience Imaging (P. Fox), Human Imaging (G. Clarke), and, Diagnostic Radiology (M. Habes) and partners with an R25 Medical Scientist Training Program (MSTP, PI Cavazos who also leads the STAC REC) to train MD/PhD scientists.