NORTHWESTERN Alzheimer's Disease Research Center

项目摘要--总体构成部分 西北ADRC已经是第25个年头了。本续订申请描述了上一个周期的进展情况 以及今后5年的行动计划，在此期间，我们将实现以下主要目标： 1)支持西北大学在生物学、早期诊断、风险因素和 通过汇集基础和临床研究人员来治疗痴呆症。 2)通过使用UDS-3参与利用NIA中心优势的国家协作 和FTLD模块，将数据传输到NACC，并参与ADNI、ADCS、NCRAD、LOAD、 ADGC和FTLD相关财团。 3)在FTLD神经病理学、原发性进行性失语(PPA)、痴呆方面发挥领导作用 与TDP-43病理、中年发作性AD(MOAD)、小胶质细胞和神经炎症有关，以及 异常成功的大脑老化(SuperAging)与西北地区的独特优势保持一致 ADRC在这一领域对衰老和痴呆症进行研究。 4)培训研究员和初级教员，并通过认证吸引新的研究人员进行痴呆症研究 临床奖学金、发展项目奖和培训补助金。 5)确保患者、家庭和未得到充分服务的人群是相关进展的受益者 通过教育、外展和新颖的生活丰富计划。 ADRC的核心被配置为服务于上面列出的特定目标。行政核心将是 负责整个ADRC的临床、科学和财政领导，以及与 国家联合体和发展项目的选择。临床核心中心将维持一批井喷- 为解决正在进行的研究重点而招募的受试者的特征。数据管理与统计 CORE将确保以最大限度地协作和生物统计咨询的方式存储数据 在研究的设计和解释中起着关键作用。神经病理学的核心将是 根据最新标准来进行尸检的患者，并分发组织、切片、DNA和数据 地方和国家的合作。外展、招聘和参与核心将与临床 核心以加强参与者在亚洲发展研究中心的招募和留住，并将发展创新的生活丰富 服务于患者及其家属的计划。研究教育部分将监督多样性 招聘研究人员和初级教员，协调负责人员的培训要求 研究的进行。成像生物标记物核心将执行最新的临床多模式神经成像 核心参与者，包括淀粉样蛋白和tau PET。执行委员会由所有关键人员组成， 将根据地方和国家的授权制定ADRC的优先事项，并将审查患者的请求， 控制、组织和数据。

PROJECT SUMMARY - OVERALL COMPONENT The Northwestern ADRC is in its 25th year. This renewal application describes the progress of the past cycle and a plan of action for the next 5 years, during which we will pursue the following principal goals: 1) Support innovative research at Northwestern University on the biology, early diagnosis, risk factors, and treatment of dementias by bringing together basic and clinical investigators. 2) Participate in national collaborations that leverage the strengths of the NIA Centers by using the UDS-3 and FTLD Module and transmitting data to NACC, and participating in ADNI, ADCS, NCRAD, LOAD, ADGC, and FTLD-related consortia. 3) Serve a leadership role in FTLD neuropathology, primary progressive aphasia (PPA), dementias associated with TDP-43 pathology, mid-life onset AD (MOAD), microglia and neuroinflammation, and unusually successful brain aging (SuperAging) in keeping with the unique strengths of the Northwestern ADRC in this area of aging and dementia research. 4) Train fellows and junior faculty and attract new investigators to dementia research through accredited clinical fellowships, Development Project awards, and training grants. 5) Ensure that patients, families, and underserved populations are beneficiaries of relevant advances through education, outreach, and novel life enrichment programs. The cores of the ADRC are configured to serve the specific goals listed above. The Administrative Core will be responsible for the clinical, scientific and fiscal leadership of the entire ADRC, as well as the coordination with national consortia and the selection of Development Projects. The Clinical Core will maintain a cohort of well- characterized subjects recruited to address ongoing research priorities. The Data Management and Statistics Core will ensure that the data are stored in ways that maximize collaboration and that biostatistical consultation plays a key role in the design and interpretation of research. The Neuropathology Core will characterize patients who come to autopsy according to up-to-date criteria, and distribute tissue, slides, DNA, and data for local and national collaborations. The Outreach, Recruitment and Engagement Core will work with the Clinical Core to enhance participant recruitment and retention in the ADRC, and will develop innovative life enrichment programs to serve patients and their families. The Research Education Component will oversee diversity recruitment for researchers and junior faculty and coordinate training requirements for the Responsible Conduct of Research. The Imaging Biomarker Core will perform up-to-date multimodal neuroimaging of Clinical Core participants, including amyloid and tau PET. The Executive Committee, composed of all key personnel, will formulate ADRC priorities based on local and national mandates and will review requests for patients, controls, tissue, and data.