Northwestern ADRC Non competing supplement application

西北 ADRC 非竞争性补充申请

• 批准号: 10577047
• 负责人: ROBERT J VASSAR
• 金额: $ 28.9万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10577047
• 关键词: Administrative Supplement; Autopsy; Brain; Budgets; Chemicals; Clinical; Enrollment; Excision; Funding; Growth; Home; Hospital Departments; Hospitals; Inpatients; Medicine; Participant; Pathology; Patients; Physicians; Policies; Reagent; Research; Services; Shipping; Structure; Time; cost; hospice environment; neuropathology; pandemic disease; programs; ranpirnase; tissue processing

On behalf of the Northwestern ADRC, we are submitting this supplement application to request funding for expenses that were not requested in our P30 budget to support our brain autopsy program, because they were not required at the time of our initial application. As of January 2022, the Northwestern Memorial Hospital (NMH) Department of Pathology changed their billing policy for all hospital-incurred autopsies. Up to that date, all autopsies on any patient who was affiliated with a Northwestern Medicine physician were complimentary, including those obtained for the research participants enrolled in the Northwestern ADRC Clinical Core. All costs were covered including those for brain removal and storage and tissue processing. From January 2022 onward, this policy has changed such that free autopsies are provided only on those patients who expire while they are inpatients admitted to the hospital at NMH. Since most of our participants die at home or in hospice or at another hospital, we will require additional funding that was not requested in our prior applications, particularly in the last 5 year competing renewal, funded in 2021. As a result, the current application is requesting a supplement to cover the costs of brain autopsies carried out in the Department of Pathology at NMH for the Northwestern ADRC Clinical Core. Our Center estimates to conduct 50 brain autopsies per year at NMH. The request (see budget justification) includes the cost for brain removal and storage, tissue processing, and chemicals and reagents required for storage and processing. In addition, on occasion, our ADRC Neuropathology Core is asked to assist in brain removal for a participant at another ADRC who lives close to our facility. We are thus also asking for costs to cover brain removal, storage and shipping for those instances. Our brain autopsy program has been highly successful and even during the pandemic benefitted from the Department of Pathology's careful adjustments to allow safe brain removal of participants who have died since the pandemic began.

我们代表西北ADRC提交这份补充申请，以请求为 我们的P30预算中没有要求支持我们的脑部尸检计划的费用，因为它们是 在我们首次申请时并不需要。截至2022年1月，西北纪念医院 (NMH)病理部门改变了他们对所有医院引起的尸检的计费政策。在此之前， 任何与西北医学内科医生有关联的患者的所有尸检都是免费的， 包括参加西北ADRC临床核心研究的研究参与者获得的数据。全 费用包括大脑移除和储存以及组织处理的费用。从2022年1月起 从现在起，这项政策已经改变，只为那些过期的患者提供免费尸检。 他们是在NMH医院住院的患者。由于我们的大多数参与者都死在家里或临终关怀院或 在另一家医院，我们需要额外的资金，这是我们之前的申请中没有要求的， 特别是在最近5年的竞争性续签中，于2021年获得资金。因此，当前的应用程序是 要求追加经费，以支付在病理学系进行的脑部尸检费用： 西北ADRC临床核心中心的NMH。我们的中心估计每年进行50次脑部尸检 在NMH。这项要求(见预算理由)包括大脑切除和储存、组织的费用 加工，以及储存和加工所需的化学品和试剂。此外，有时我们的 ADRC神经病理核心被要求帮助另一名住在ADRC的参与者摘除大脑 离我们工厂很近。因此，我们还要求支付移除大脑、存储和运输这些设备的费用 实例。我们的脑部尸检计划非常成功，甚至在大流行期间也受益 来自病理学系的仔细调整，以允许安全地切除那些有 自大流行开始以来死亡。