Northwestern ADRC Non competing supplement application

西北 ADRC 非竞争性补充申请

• 批准号: 10577047
• 负责人: ROBERT J VASSAR
• 金额: $ 28.9万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10577047
• 关键词: Administrative Supplement; Autopsy; Brain; Budgets; Chemicals; Clinical; Enrollment; Excision; Funding; Growth; Home; Hospital Departments; Hospitals; Inpatients; Medicine; Participant; Pathology; Patients; Physicians; Policies; Reagent; Research; Services; Shipping; Structure; Time; cost; hospice environment; neuropathology; pandemic disease; programs; ranpirnase; tissue processing

On behalf of the Northwestern ADRC, we are submitting this supplement application to request funding for expenses that were not requested in our P30 budget to support our brain autopsy program, because they were not required at the time of our initial application. As of January 2022, the Northwestern Memorial Hospital (NMH) Department of Pathology changed their billing policy for all hospital-incurred autopsies. Up to that date, all autopsies on any patient who was affiliated with a Northwestern Medicine physician were complimentary, including those obtained for the research participants enrolled in the Northwestern ADRC Clinical Core. All costs were covered including those for brain removal and storage and tissue processing. From January 2022 onward, this policy has changed such that free autopsies are provided only on those patients who expire while they are inpatients admitted to the hospital at NMH. Since most of our participants die at home or in hospice or at another hospital, we will require additional funding that was not requested in our prior applications, particularly in the last 5 year competing renewal, funded in 2021. As a result, the current application is requesting a supplement to cover the costs of brain autopsies carried out in the Department of Pathology at NMH for the Northwestern ADRC Clinical Core. Our Center estimates to conduct 50 brain autopsies per year at NMH. The request (see budget justification) includes the cost for brain removal and storage, tissue processing, and chemicals and reagents required for storage and processing. In addition, on occasion, our ADRC Neuropathology Core is asked to assist in brain removal for a participant at another ADRC who lives close to our facility. We are thus also asking for costs to cover brain removal, storage and shipping for those instances. Our brain autopsy program has been highly successful and even during the pandemic benefitted from the Department of Pathology's careful adjustments to allow safe brain removal of participants who have died since the pandemic began.

代表西北ADRC，我们提交了这份补充申请，要求资助 我们的P30预算中没有要求用于支持我们的大脑解剖计划的费用，因为它们 在我们最初申请时不需要。截至2022年1月，西北纪念医院 (NMH)病理科改变了所有医院尸检的收费政策。到那时为止， 所有与西北医学医生有联系的病人的尸检都是免费的， 包括那些参加西北ADRC临床核心的研究参与者。所有 费用包括脑切除和储存以及组织处理的费用。自2022年1月起 此后，这项政策发生了变化，仅对那些在死亡期间死亡的患者提供免费尸检， 他们是NMH医院的住院病人。由于我们的大多数参与者都是在家中或临终关怀中心去世的， 在另一家医院，我们将需要额外的资金，这是我们以前的申请中没有要求的， 特别是在2021年资助的最后5年竞争性更新中。因此，当前的应用程序是 要求补充，以支付在病理学系进行的脑尸检的费用， 西北ADRC临床核心的NMH。我们中心估计每年进行50次脑解剖 在NMH。所需经费（见预算理由）包括大脑切除和储存、组织 处理以及储存和处理所需的化学品和试剂。此外，有时，我们 ADRC神经病理学核心被要求协助大脑切除的参与者在另一个ADRC谁的生活 靠近我们的设施。因此，我们还要求支付为这些人进行大脑切除、储存和运输的费用。 实例.我们的大脑解剖项目非常成功，即使在大流行期间， 从病理学系的仔细调整，以允许安全的大脑切除参与者谁有 自从大流行开始以来，