Histology Core

摘要 UND的组织学核心是为了改善支持我们的成功的基础设施 第一阶段寄主病原体相互作用卓越中心在该大学的实施 北达科他州医学与健康科学学院。核心的开发是为了提供高质量 器械、组织准备、染色、图像分析服务和广泛领域的培训 为科布雷研究人员提供基本和先进的组织学技术。核心还提供 接触和支持联合国开发计划署SMHS内外的非科布雷调查员，以及来自 邻近的机构(美国农业部-大福克斯人类营养研究中心)和邻近城市(北部 北达科他州的达科他州立大学主要是本科院校和部落学院)。《核心》 仍然是在UND成功发展宿主病原体相互作用企业和完成 本次第二阶段续签申请中提出的四个项目。核心从一个主要的 提供用户培训的共享设备设施，现在是为整个地区的用户提供完整的送货服务设施 北达科他州大学校园。多种组织切片和染色服务与整个幻灯片Brightfield或 荧光成像和图像量化使核心对研究的增长具有无价的价值 在UND的进取心。在第二阶段，核心将继续协助Cobre团队成员和更广泛的 具有专门针对特定应用样本的实验设计的UD/ND研究社区 制备技术、确定可用的适当分析工具、分辨率限制和定量 形态技术。核心还将为Cobre和其他人提供服务、培训和指导 用户在仪器使用的方方面面，安全，组织样本的准备，以及协助故障排除的所有方面 组织制备和分析方面。最后，核心将实施一项业务计划，其中包括 继续扩大用户基础的战略，并在组织的所有方面提供收费服务援助- 和免疫化学检测方法和分析，从而铺平了一条长期可持续的道路 核心。

Summary The Histology Core at UND was established to improve the infrastructure supporting our successful implementation of the Phase 1 Center for Excellence in Host Pathogen Interactions COBRE at the University of North Dakota School of Medicine and Health Sciences. The Core was developed to provide high quality instrumentation, tissue preparation, staining, image analysis services, and training in a wide spectrum of fundamental and advanced histological techniques to COBRE research investigators. The Core also provides access and support to non-COBRE investigators within and outside the UND SMHS, as well as those from institutions adjoining (USDA-Grand Forks Human Nutrition Research Center) and in neighboring cities (North Dakota State University, North Dakota primarily undergraduate institutions and tribal colleges). The Core remains essential for successful growth of the host pathogen interaction enterprise at UND and completing al four of the projects proposed in this Phase 2 renewal application. The Core evolved from being a primarily shared equipment facility with provided user training to now a complete drop off service facility for users across the UND campus. Multiple tissue sectioning and staining services coupled with whole slide brightfield or fluorescent imaging and image quantitation have made the Core invaluable to growth of the research enterprise at UND. In Phase 2, the Core will continue to assist COBRE team members and the broader UND/ND research community with experimental design specifically with regards to application-specific sample preparation techniques, identifying appropriate analytical tools available, resolution restrictions, and quantitative morphological techniques. The Core will also provide service, training, and instruction to COBRE and other users in all aspects of instrument use, safety, tissue sample preparation, and aid with trouble shooting all aspects of tissue preparation and analysis. Finally, the Core will implement a business plan that includes strategies to continue expanding the user base and provide fee-for-service assistance in all aspects of histo- and immunochemical detection methods and analyses, thus paving a way to long-term sustainability of the Core.