University of Louisville Center for Integrative Environmental Health Sciences

基金资助的奖学金项目摘要 路易斯维尔大学综合环境健康科学中心（CIEHS）汇集了 一个多学科的调查小组，共同努力，制定一个框架，以了解复杂的 并整合环境毒物、生活方式因素、生命阶段、遗传和 性别及其在人类健康和疾病中的作用。CIEHS具有独特的优势，可以建立跨学科的 小组，以解决这些问题，凭借其成员的多学科专门知识和其地理 位置.路易斯维尔地区社区，由大都会路易斯维尔和西部的县组成。 肯塔基州是一个独特的城市和农村环境的混合体，工业和农业暴露， 美国的缩影。该地区受到慢性病（如心血管病、糖尿病、 癌症等），都是由环境因素引起的，都是全国最高的。CIEHS促进了 研究和培训的重点是：（1）接触工业化学品目前在城市和农村肯塔基州 环境（金属、挥发性有机化合物、多氯联苯、氯乙烯等），(2)生活方式因素（饮食，酒精，社会经济 压力源、肥胖等），以及对生命阶段、遗传学和性别在发展中的反应的修改， 慢性成人疾病CIEHS分为三个多学科研究兴趣小组（多机构 毒理学、癌症和神经发育毒理学）。综合健康科学设施核心促进 基础科学的翻译，包括成人和儿科临床试验的协助。社区 Engagement Core促进CIEHS调查人员与社区之间的多方位沟通 特别关注农村保健提供者和青年群体。试点项目提供 支持新的环境卫生调查人员的资源，CIEHS成员之间的合作， 建立调查带来了新的技能，以环境健康问题，新的途径， CIEHS成员的环境健康研究，以及社区参与和社区领导的研究， 与CIEHS成员合作。职业发展计划为新员工提供指导和支持， 初级和中级调查员。这些活动得到两个设施核心（生物统计和 信息学以及综合毒理学和环境测量）。CIEHS在以下方面发挥领导作用： 环境健康研究，促进对长期暴露于环境中的相互作用的调查。 毒物和生活方式因素的发病机制，并制定下一代的环境健康 研究人员我们的研究利用实验室中的模型系统，通过调查更大的生态系统， 污染对野生动物的影响，以及路易斯维尔地区社区提供的人类实验室， 与社区合作伙伴的合作。

PROJECT SUMMARY OF THE FUNDED PARENT GRANT The University of Louisville’s (UofL) Center for Integrative Environmental Health Science (CIEHS) brings together a multidisciplinary group of investigators working together to develop a framework to understand the complexities of and to integrate the interactions between environmental toxicants, life style factors, life stage, genetics and gender and their roles in human health and disease. The CIEHS is uniquely positioned to build transdisciplinary teams to tackle these problems by virtue of the multidisciplinary expertise of its members and its geographic location. The Louisville Regional Community, composed of Metropolitan Louisville and the counties of western Kentucky, is a unique mix of urban and rural environments with industrial and agricultural exposures that is a microcosm of the United States. The region is plagued by rates of chronic disease (e.g. cardiovascular, diabetes, cancer, etc.), all with environmental etiologies, that are among the highest in the nation. The CIEHS facilitates research and training focused on: (1) exposure to industrial chemicals present in the urban and rural KY environments (metals, VOCs, PCBs, vinyl chloride, etc.), (2) lifestyle factors (diet, alcohol, socioeconomic stressors, obesity, etc.), and the modifications to response by life stage, genetics and gender in development of chronic adult diseases. CIEHS is organized into three multi-disciplinary research interest groups (multi-organ toxicology, cancer, and neurodevelopmental toxicology). The Integrated Health Science Facility Core promotes translation of basic science including assistance with both adult and pediatric clinical trials. The Community Engagement Core promotes multi-directional communication between CIEHS investigators and community groups with special focus on rural health care providers and youth groups. The Pilot Project Program provides resources supporting new environmental health investigators, collaborations between CIEHS members and established investigators bringing new skill sets to environmental health problems, new avenues of environmental health research by CIEHS members, and community-engaged and community-led research in collaboration with CIEHS members. A Career Development Program provides mentorship and support to new junior, as well as mid-level, investigators. These activities are supported by two facility cores (biostatistics and informatics, and integrated toxicomics and environmental measurements). The CIEHS provides leadership in environmental health research, promotes investigation of the interactions of chronic exposure to environmental toxicants and lifestyle factors in pathogenesis, and develops the next generation of environmental health researchers. Our studies utilize model systems in the laboratory, the larger ecosystem by investigation of pollution effects on wildlife, and the human laboratory provided by the Louisville Regional Community in collaboration with community partners.