Molecular Mycology: Current Approaches to Fungal Pathogenesis (MoMy) Training Course

项目总结 此应用程序的目的是支持分子真菌学和病理学教育计划 在马萨诸塞州伍兹霍尔的海洋生物实验室(MBL)。妈咪现在快到第25届了 在MBL的周年纪念。在该课程的历史上，它为科学工作者提供了关键的培训，以 满足与世界生物医学研究相关的日益增长的发病率和有限的治疗需求 人类真菌感染的选择。简而言之，迫切需要对人类进行新的研究 真菌感染，因为免疫调节医学疗法的快速发展往往会导致 机会性真菌感染。Momy已经解决了真菌对发病率和 免疫受损患者群体的死亡率以及真菌作为微生物组的作用 影响健康和疾病的组件。我们的密集和身临其境的妈妈计划为学员提供 由真菌生物学、免疫学和宿主领域的顶尖科学家提供的动手实验室技能培训 反应，以及抗真菌药物的开发。这些技能对于发展和促进训练有素的 面对真菌对人类福祉构成的日益严重的威胁，我们必须为劳动力提供帮助。妈妈的目标是 为期两周的课程是提供基础知识和培训的技术，程序和 通过与真菌和真菌动物模型的直接工作经验了解分子真菌学概念 疾病。重要的是，妈妈提供重要的职业指导和职业发展机会 在整个课程中提供给所有参与者。我们实现目标的部分原因是通过 来自真菌学社区的顶尖专家的多元化和尽职尽责的教师。我们的具体目标是 内容包括：(1)深入讲授分子医学真菌学的当代基本技能； (2)提供基于前沿分子方法和概念的指导研究机会 医学真菌学；及(3)为学员提供职业辅导，包括专业发展 提供咨询、科学道德培训，并发展终身专业指导网络。总的来说， 莫米在成功实现这些目标方面有着悠久的历史，以推进NIH任务和推进我们的 能够提出、探索和回答与真菌对人类健康影响有关的关键问题。这个 鉴于真菌影响的范围和发生率不断增加，当然仍然具有极其重要的意义 人类和我们领域中正在发生的快速研究、技术和概念进步。

PROJECT SUMMARY The purpose of this application is to support the Molecular Mycology and Pathogenesis education program (MOMY) at the Marine Biological Laboratory (MBL) in Woods Hole, MA. MOMY is now approaching its 25th anniversary at the MBL. Over the course’s history it has provided pivotal training for a scientific workforce to meet the world’s biomedical research needs related to the growing incidence of, and limited therapeutic options for, human fungal infections. Simply put, there is an urgent need for new research with human fungal infections given the rapid advances in immune modulating medical therapies that often result in opportunistic fungal infections. MOMY has addressed both the significant impact of fungi on morbidity and mortality in immune compromised patient populations, as well as the role of fungi as microbiome components that affect health and disease. Our intensive and immersive MOMY program provides trainees hands-on laboratory skill training by leading scientists in the fields of fungal biology, immunology & host response, and antifungal drug development. These skills are critical to develop and promote a well-trained workforce in the face of the growing threat posed by fungi to human well-being. MOMY’s objective during the 2 week course is to provide foundational knowledge and training in the techniques, procedures, and concepts in molecular mycology through direct experiences working with fungi and animal models of fungal disease. Importantly, MOMY provides critical career mentoring and professional development opportunities throughout the course to all participants. We achieve our objective in part through the participation of a diverse and committed faculty who are leading experts from the mycology community. Our specifics aims are: (1) To provide in-depth instruction on fundamental contemporary skills in molecular medical mycology; (2) To provide mentored research opportunities based on cutting edge methods and concepts in molecular medical mycology; and (3) To provide trainees with career mentoring, including professional development advice, science ethics training, and development of a lifelong professional mentoring network. Overall, MOMY has a long history of successfully meeting these aims to advance the NIH Mission and advance our ability to ask, explore, and answer critical questions related to the impact of fungi on human health. The course remains of utmost significance given the increasing scope and incidence of fungi’s impact on humanity and the rapid research technological and conceptual advances occurring in our field.