Informatics, Coordination and Service Center for the Mutant Mouse Resource and Research Centers

项目概要-总体 突变小鼠资源和研究中心（MMRRC）是NIH的首要知识库， 冷冻保存和分配基因工程和自发突变的小鼠等位基因， 活小鼠、种质、胚胎干细胞和其他细胞系。MMRRC的四个育种和分布 加州大学戴维斯分校（加利福尼亚州）、查佩尔山（北卡罗来纳州）、密歇根大学哥伦比亚分校（密苏里州）和杰克逊实验室（ME）的设施如下： 通过信息学、协调和服务中心（ICSC）集中组织， MMRRC的网络存在，并为生物医学研究社区提供客户服务。因此， ICSC负责所有MMRRC订单处理、菌株捐赠协调、数据管理、指标， 以及该联盟的公众教育和外展活动。该特定应用的目的是 ICSC在加州大学戴维斯分校校园的持续运作。这将通过三个指定的核心来完成 满足MMRRC（1）协调，（2）客户服务和公共关系，以及（3）信息学。每个核心 项目负责人将指导旨在扩大MMRRC的业务和卓越的活动。更具体地说， 协调核心将促进内部和外部MMRRC的互动和协作，管理 技术人员，组织MMRRC与ORIP/DPCPSI/OD/NIH计划官员的交流，并协调 进度报告以及实地考察。客户服务和公共关系核心将作为第一点， 联系捐赠，数据，并从研究社区的订单查询，使用基于网络的互动，以及 作为在专业会议上的面对面代表，除了有针对性地努力提高对 MMRRC作为一个宝贵的研究资源。信息学核心将负责开发， 实施、扩展和维护MMRRC网站，以及与之相关的关系数据库， 所有ICSC服务，ICSC托管的通信服务，指标报告和分析营销 努力国际公务员制度委员会还将开展一个应用研究项目，研究《千年宣言》对以下方面的影响： 研究社区在整个，使用监督的文献分析。在目前的领导下，公务员制度委员会- 协调MMRRC财团已增加其用户群超过50%，几乎翻了一番，其持有量和订单， 在2019年达到历史最高水平。这是通过简化捐赠和订单处理来实现的， 通过有针对性的社交媒体和电子邮件活动，利用创新的、以用户为中心的信息技术。的 因此，公务员制度委员会在加州大学戴维斯分校的运作非常适合这一供资机会的目的，即促进 MMRRC作为NIH的首选资源，确保实验设计和质量控制的最高标准 优化突变小鼠研究的重复性。这一点很重要，因为它直接迎合了美国国立卫生研究院 其使命是促进研究，以产生强大的和可重复的结果，促进人类健康。

PROJECT SUMMARY – OVERALL The Mutant Mouse Resource and Research Centers (MMRRC) is the NIH’s premier repository for the cryopreservation and distribution of genetically engineered and spontaneously mutated mouse alleles held as live mice, germplasm, and embryonic stem and other cell lines. The MMRRC’s four breeding and distribution facilities at UC Davis (CA), UNC Chapel Hill (NC), UM Columbia (MO), and The Jackson Laboratories (ME) are centrally organized through the Informatics, Coordination and Service Center (ICSC), which maintains the MMRRC’s web presence and provides customer service to the biomedical research community. As such, the ICSC is responsible for all MMRRC order processing, the coordination of strain donations, data curation, metrics, and the consortium’s public education & outreach campaign. The objective of this particular application is the continued operation of the ICSC at the UC Davis campus. This will be accomplished with three designated Cores that cater to MMRRC (1) Coordination, (2) Customer Service & Public Relations, and (3) Informatics. Each Core’s Project Lead will direct activities designed to expand the MMRRC’s operations and excellence. More specifically, the Coordination Core will facilitate internal as well as external MMRRC interactions and collaborations, manage technical staff, organize MMRRC exchanges with the ORIP/DPCPSI/OD/NIH Program Official, and coordinate progress reports as well as site visits. The Customer Service & Public Relation Core will act as the first point of contact for donation, data, and order inquiries from the research community, using web-based interaction as well as face-to-face representation at professional conferences in addition to targeted efforts to raise awareness of the MMRRC as a valuable research resource. The Informatics Core will be responsible for the development, implementation, expansion, and maintenance of the MMRRC website, the relational databases associated with all ICSC services, communication services hosted at the ICSC, metrics reporting, and the analytical marketing effort. The ICSC will furthermore engage an Applied Research Project examining the impact of the MMRRC on the research community at large, using supervised literature analyses. Under its current leadership, the ICSC- coordinated MMRRC consortium has increased its user base by >50%, nearly doubled its holdings, and orders reached an all-time high in 2019. This was accomplished by streamlining donation and order processing and through targeted social media and email campaigns with innovative, user-centered information technology. The ICSC operation at UC Davis is, hence, well suited for this funding opportunity’s purpose, namely to promote the MMRRC as the NIH go-to resource to ensure the highest standards of experimental design and quality control to optimize the reproducibility of mutant mouse research. This is significant because it caters directly to the NIH mission of promoting research to generate robust and reproducible results for the advancement of human health.