Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart Study

项目摘要 中年的心血管(CV)危险因素被认为影响晚年的认知状态。结果来自 临床试验表明，修改老年人的心血管危险因素可能是降低晚期风险的一个有希望的途径。 生活认知能力下降。在此，我们建议在母公司拨款2RF1AG041200的范围内，提出一项补编，题为 《终生心血管风险暴露与阿尔茨海默病相关脑健康：博加卢萨心脏研究》旨在确定 这些疾病以种族和性别特有的方式共享的可修改的风险因素，并决定了关键时间 预防和推迟阿尔茨海默病和相关痴呆综合征(ADRD)发病的窗口，并尽量减少 差距。家长拨款将收集600名亚临床患者的认知表现和神经成像方面的信息 脑损伤200名参加博加卢萨心脏研究(BHS)的中年黑人和白人男性和女性。这个 候选人De Anda-Duran博士将通过应用先进的分析方法，利用父母拨款收集的数据 这将区分影响大脑功能的心血管风险因素的一生(童年至中年)轨迹。这部作品 我将扩展传统的神经心理学(NP)方法，通过识别 可能更容易进展为ADRD的亚临床NP表型。轻度认知障碍(MCI)是 关键阶段通常导致进展为ADRD；然而，准确识别这一先兆是具有挑战性的，并且 不一致可能导致ADRD的神经病理异质性。充足和及时 使用数据表征更有可能进展为痴呆和/或类似MCI的神经认知表型- 驱动型方法可能是解决疾病负担和优化患者临床试验资格的潜在途径 和降低风险干预措施。数据驱动的方法在识别和分类个人方面似乎更精确 基于不同的NP表型与不太模糊的神经病理联系。为此，我们建议评估 黑人和白人参与者一生暴露于心血管危险因素与中年NP表型的关系 来自路易斯安那州博加卢萨的一个以社区为基础的半农村中年人队列。这项工作具有重要的意义 对临床和公共卫生的影响。早期的认知表型特征可能会更好地识别倾向于 可能对临床干预更敏感的认知障碍综合征和高危人群的进展， 并从有针对性的预防战略中获益最多。此外，拟议的补编将为候选人Dr。 De Anda-Duran，有必要的保护期，以获得成为独立投资者所需的技能 研究员。

Project Summary Cardiovascular (CV) risk factors in midlife are recognized to influence later-life cognitive status. Results from clinical trials have suggested that modifying CV risk factors in older adults may be a promising avenue to lower risk of late life cognitive decline. Herein, we propose a supplement, within the scope of the parent grant 2RF1AG041200, entitled ‘Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart Study’ which aims to identify modifiable risk factors shared by these conditions in a race- and sex-specific fashion, and determine the critical time windows to prevent and delay the onset of Alzheimer’s Disease and related dementia syndromes (ADRD) and minimize disparities. The parent grant will collect information on cognitive performance among 600 and neuroimaging of sub-clinical brain injury 200 black and white men and women who participate in the Bogalusa Heart Study (BHS) in middle age. The candidate Dr. De Anda-Duran, will leverage the data collected by the parent grant, by applying advanced analytical methods that will distinguish life-course (childhood to midlife) trajectories of CV risk factors that impact brain function. This work will expand on traditional neuropsychological (NP) approaches to characterize midlife cognitive performance by identifying subclinical NP phenotypes that may be more susceptible to progression to ADRD. Mild cognitive impairment (MCI) is a pivotal stage often leading to progression to ADRD; however, accurate identification of this prodrome is challenging, and inconsistencies might contribute to the neuropathological heterogeneity seen in ADRD. Adequate and timely characterization of neurocognitive phenotypes that more likely progress to dementia, and/or resemble MCI, using data- driven approaches can be a potential pathway to address disease burden and optimize patient eligibility for clinical trials and risk reduction interventions. Data-driven approaches appear to be more precise in identifying and classifying individuals based on distinct NP phenotypes linked with less ambiguous neuropathology. To this end, we propose to evaluate the relationship between life-course exposure to CV risk factors and midlife NP phenotypes among black and white participants from a semi-rural, community-based cohort of middle-aged adults located in Bogalusa, Louisiana. This work has important clinical and public health implications. Early characterization of cognitive phenotypes may better identify groups prone to progress to cognitive impairment syndromes and high-risk groups who may be more responsive to clinical interventions, and benefit most from targeted prevention strategies. Moreover, the proposed supplement will provide the candidate, Dr. De Anda-Duran, with the necessary period of protected time to gain the skills required to become and independently funded researcher.