Cardiorenal and Metabolic Diseases Research Center

总体来说 项目摘要/摘要 心血管疾病、肾脏疾病和代谢性疾病有着千丝万缕的联系，是导致死亡的主要原因 以及美国的发病率，特别是在密西西比州，密西西比州的发病率是全国最高的 疾病。心肾功能紊乱和代谢紊乱通常聚集在一起，高度相互依存。肥胖 以及相关的代谢紊乱，如糖尿病，是心血管疾病和肾脏疾病的主要原因。 肾功能异常是高血压的重要原因和后果，高血压是高血压的关键危险因素 心血管疾病，如冠状动脉疾病和中风。了解简历之间的复杂关系， 肾脏疾病、代谢疾病和开发新的治疗方法需要研究范式的转变 它结合了多学科的综合方法，结合了基础、临床和人口的努力 科学家。此阶段3 Cobre提案的主要目标是扩大阶段1和阶段2的成功 开发领先的心肾和代谢性疾病研究中心(CMDRC)，将 由基础、临床和人口科学家组成的多学科小组，致力于共同的协同主题，以及 以促进他们的合作。第三阶段的具体目标是：1)进一步发展CMDRC基础设施， 组织良好的高效试点项目计划(PPP)和可持续的研究核心设施， 培养在心肾和代谢性疾病的基础、临床和人群研究方面的卓越表现，并增加 CMDRC研究人员对NIH和其他国家生物医学机构独立资助的竞争力 研究计划；2)加强CMDRC指导和教育计划，为PPP提供支持 研究人员以及其他有前途的研究人员，这样他们就可以变得富有成效，独立 研究人员也是多学科研究团队的有效协作者；3)扩大我们的渠道 不同的博士后研究员和受过尖端心肾和代谢性疾病研究培训的学生 因此他们成为这一领域的下一代研究人员；主要强调招聘和 通过与当地机构的伙伴关系和通过利用 UMMC的培训计划；4)加强老牌和初级员工之间的合作和互动 来自UMMC心肾和代谢性疾病多学科的研究人员，其他想法得到支持 计划和外部合作伙伴。这些互动将利用UMMC和其他想法提供的资源 方案；5)进一步扩大高生产率、外部资助的心肾和新陈代谢项目的数量 UMMC的疾病研究人员通过利用机构资源招聘更多的新教员 临床和转化性研究方面的专业知识，以及在CMDCR专业知识方面存在差距的领域。这个 CMDRC一直是心肾和代谢性疾病研究显著扩大的主要驱动力 密西西比州。第三阶段的支持将扩大并确保我们开发高效的 CMDRC致力于通过研究、发现和创新来改善生活。

OVERALL PROJECT SUMMARY/ABSTRACT Cardiovascular (CV), renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the U.S., especially in Mississippi which has the highest prevalence in the nation of these diseases. Cardiorenal and metabolic disorders usually cluster together and are highly interdependent. Obesity and associated metabolic disorders, such as diabetes mellitus, are major causes of CV and renal disease. Abnormal kidney function is an important cause as well as a consequence of hypertension, a key risk factor for CV diseases such as coronary artery disease and stroke. Understanding the complex relationships among CV, renal, and metabolic disorders and developing new therapeutic approaches requires a paradigm shift in research that incorporates multidisciplinary integrated approaches, combining the efforts of basic, clinical and population scientists. A major objective of this Phase 3 COBRE proposal is to amplify the success of Phases 1 and 2 in developing a leading Cardiorenal and Metabolic Diseases Research Center (CMDRC) that brings together a multidisciplinary group of basic, clinical and population scientists working on a common synergistic theme, and to facilitate their collaborations. The specific aims for Phase 3 are: 1) To further develop CMDRC infrastructure, a well-organized highly productive Pilot Projects Program (PPP), and sustainable research core facilities that foster excellence in basic, clinical, and population research in cardiorenal and metabolic diseases and increased competitiveness of CMDRC investigators for independent funding from NIH and other national biomedical research programs; 2) To enhance CMDRC mentoring and education programs that provide support for PPP investigators as well as other promising researchers so that they can become productive, independent investigators who are also effective collaborators on multidisciplinary research teams; 3) To amplify our pipeline of diverse postdoctoral fellows and students trained in cutting-edge cardiorenal and metabolic diseases research so they become the next generation of researchers in this field; major emphasis is placed on recruiting and mentoring underrepresented minority investigators through partnerships with local institutions and by leveraging training programs at UMMC; 4) To enhance collaborations and interactions among established and junior investigators from multiple disciplines in cardiorenal and metabolic diseases at UMMC, other IDeA supported programs, and external partners. These interactions will leverage resources provided by UMMC and other IDeA programs; 5) To further expand the number of highly productive, extramurally funded cardiorenal and metabolic disease researchers at UMMC by leveraging institutional resources to recruit additional new faculty with expertise in clinical and translational research, and in areas where there are gaps in CMDCR expertise. The CMDRC has been a major driver for marked expansion of cardiorenal and metabolic diseases research in Mississippi. Phase 3 support will amplify and ensure sustainability of our efforts to develop a highly productive CMDRC dedicated to improving lives through research, discovery, and innovation.