Stem Cells and Aging

整体 摘要 生物医学研究卓越中心（COBRE）干细胞和衰老的长期目标是 建立一个多学科的干细胞和衰老生物学和治疗翻译中心，重点是 干细胞和衰老领域的潜在机制和治疗潜力。两个领域 奋进广泛重叠，一个持有组织修复的承诺，在各种各样的疾病， 另一个是影响每个人并导致死亡的疾病的根源。自从眼镜蛇计划开始以来， 17名初级研究人员已经收到了完整的项目或试点，369篇研究文章和累积 超过20，000，000美元的校外资金主要来自NIH。其中7人仍得到资助， 在其学术领域保持或发展，其中三个进入生物技术领域。因为他们的 COBRE资助，5人在布朗大学获得晋升。COBRE第三阶段的主要目标是 加强和过渡的COBRE研究基础设施成为一个有竞争力的，独立的和自我的， 持续卓越的学术中心-中心干细胞和衰老生物学和治疗5 年为实现这一主要目标，提出了以下四个具体目标。1)为了提供强有力的领导， 结构和支持，以加强翻译干细胞和衰老研究，通过提供关键设备， 在流式细胞术、病毒构建和细胞外分离和表征方面拥有独特的专业知识。2)到 通过以下方式促进和开发流式细胞术、慢病毒构建体和细胞外囊泡核心 评估和关注核心的业绩，以实现长期独立性，可持续性， 区域增长。3)指导转译干细胞和衰老相关研究的试点项目计划， 走向校外资金，通过支持成功的当地教师的专家指导， 行政核心。4)通过鼓励和促进罗得岛社区的转化研究， 使临床医生和基础研究人员能够在初级和高级研究人员层面进行合作。我们 我们的愿景是通过维持和转变现有的高素质研究基础设施， 临床医生与基础研究科学家、初级研究人员和高级研究人员并肩工作， 发展对干细胞和衰老的疾病和紊乱的见解，从而导致有效的临床 治疗方法。

Overall Abstract The long-term goal of the Center of Biomedical Research Excellence (COBRE) for Stem Cells and Aging is to develop a multidisciplinary translational Center for Stem Cells and Aging Biology and Therapeutics, focusing on the underlying mechanisms and therapeutic potentials in the stem cell and aging fields. The two areas of endeavor overlap extensively, one holding the promise of tissue restoration in a wide variety of disorders while the other underlies diseases that impact everyone and leads to death. Since the start of the COBRE nine years ago 17 junior investigators have received either full projects or pilots, with 369 research articles and cumulative extramural funding of over $20,000,000 largely from NIH. Seven of these individuals are still funded while 13 have sustained or advanced in their academic fields, with three entering the Biotechnology field. Since their COBRE funding, 5 have received promotions at Brown University. The main objective of the Phase 3 COBRE is to strengthen and transition the COBRE research infrastructure into a competitive, independent and self- sustaining academic center of excellence- the Center for Stem Cells and Aging Biology and Therapeutics in 5 years. To achieve this main objective four specific aims are proposed as follows. 1) To provide strong leadership, structure and support to enhance translational stem cell and aging research, by providing critical equipment and unique expertise in flow cytometry, viral construction and extracellular isolation and characterization. 2) To facilitate and develop the Flow Cytometry, Lentivirus Construct, and the Extracellular Vesicle Cores, by evaluating and focusing the performance of the Cores toward the goal of long-term independence, sustainability, and regional growth. 3) To guide the Pilot Project Program in translational stem cell and aging related research, toward extramural funding, with expert mentorship from successful local faculty through support of the Administrative Core. 4) Enhance translational research in the Rhode Island community by encouraging and enabling collaborations between clinicians and basic researchers at the junior and senior investigator levels. Our vision is by sustaining and transitioning the established high caliber research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators and senior investigators, to develop insights into diseases and disorders of stem cells and aging, leading in turn to effective clinical therapeutic approaches.