NHGRI Sample Repository for Human Genetic Research

项目总结 由NHGRI赞助并于2006年在科里尔研究所成立的NHGRI样品储存库 人类基因研究提供了一个公众可访问的、集中的、具有良好特征的资源 来自广泛的全球人类种群的生物标本，包括1000基因组计划收集， 用于生物医学研究。NHGRI资料库的目标是促进和促进这项研究 通过建立、维护和分发一个高质量的、 可再生的、可复制的、特征良好的和广泛认可的细胞系和DNA。NHGRI存储库 是一种全球资源，已被数千名研究人员用来支持无数的研究研究。 自成立以来，已有超过20万个细胞系、dna和rna样本被分发到 世界上50个国家的研究人员，以及数以千计的科学文章都是由研究产生的 使用这些样本和相关数据。建议的NHGRI存储库活动包括：(1)维护 为现有的存储库集合清点和分发NHGRI存储库细胞系和DNA样本， (2)分发定制制剂和大量DNA、高分子量(HMW)DNA、RNA、细胞球和 应科学界的要求定制板材和板材，(3)扩大资料库，以包括 来自人类Pangenome参考联盟的Biospecimen提交，并创建了一个新的 诱导的多能干细胞将包含广泛的基因组变异，以满足不断增长的需求 (4)维护一个全面和安全的数据库和公共在线目录 用于NHGRI储存库活动，并通过科学的 演示文稿、会议、教育活动和社区报告。有超过50年的NIH赞助的 生物银行的专业知识，科里尔是唯一有资格实现这些目标和战略扩大业务 和NHGRI储存库的产品。NHGRI存储库的目标与NHGRI的目标是一致的 支持加速基因组研究的资源和技术开发的使命。科里尔是一个 值得信赖的NIH合作伙伴，并拥有确保成功运营的基础设施、专业知识和记录， 维持和发展这一重要而独特的基因组资源。

PROJECT SUMMARY Sponsored by the NHGRI and established at the Coriell Institute in 2006, the NHGRI Sample Repository for Human Genetic Research provides a publically accessible, and centralized resource of well-characterized biospecimens from a wide range of global human populations, including the 1000 Genomes Project collection, for use in biomedical research. The objectives of the NHGRI Repository are to stimulate and facilitate the study of human genetic and genomic variation by establishing, maintaining, and distributing a repository of high-quality, renewable, reproducible, well-characterized, and broadly consented cell lines and DNA. The NHGRI Repository is a global resource that has been used by thousands of investigators to support countless research studies. Since its inception, over two hundred thousand cell lines, DNA and RNA samples have been distributed to researchers in 50 countries around the world, and thousands of scientific articles have resulted from studies using these samples and associated data. Proposed NHGRI Repository activities include: (1) maintaining inventory and distributing NHGRI Repository cell lines and DNA samples for the existing repository collection, (2) distributing custom preparations and lots of DNA, High Molecular Weight (HMW) DNA, RNA, cell pellets, and custom plates and panels as requested by the scientific community, (3) expanding the repository to include biospecimen submissions from the Human Pangenome Reference Consortium and creating a new panel of induced pluripotent stem cells that will encompass a wide range of genomic variation to meet the growing needs of the research community, and (4) maintaining a comprehensive and secure database and public online catalog for NHGRI Repository activities, and engaging the scientific community and public at large through scientific presentations, conferences, educational events, and community reports. With over 50 years of NIH-sponsored biobanking expertise, Coriell is uniquely qualified to achieve these aims and strategically expand the operations and offerings of the NHGRI Repository. The goals of the NHGRI Repository are consistent with the NHGRI’s mission to support development of resources and technology that accelerate genomic research. Coriell is a trusted NIH partner and has the infrastructure, expertise, and track-record to ensure the successful operations, maintenance and growth of this important and unique genomic resource.