Quantifying the Mechanism and Impact of Hip Extensor Muscle Dysfunction During Aerobic Exercise in Hip Osteoarthritis

项目总结/摘要 髋关节骨关节炎（OA）影响约25%的45岁以上人群。电流 保守治疗包括基于运动的方案，但这些干预措施在减少 髋关节OA相关临床和功能异常。这些锻炼计划的一个局限性是缺乏 用于建立这些治疗模式的证据，这导致这些计划在 治疗髋关节OA。用于告知髋关节OA人群运动计划的当前实验方案 缺乏测量髋关节肌肉功能障碍的精确度。因此，有必要建立一个 可精确测量髋关节肌肉功能障碍的实验平台。的新的实验 本申请中提出的平台将能够精确评估髋关节肌肉功能障碍，并将提供 临床医生需要制定有效的多学科的证据，保守的锻炼计划， 治疗症状性髋关节OA。 本次K 01奖的主要研究者（PI）将开发一种新颖的多模态实验平台 这将精确地测量髋关节伸肌功能障碍对有症状的髋关节OA患者的影响。 PI将利用新型成像技术和肌肉扭矩发展评估来评估 症状性髋关节OA患者髋关节伸肌功能障碍的病理机制的相应影响 在有氧运动（机械应力测试）期间，将评估以下患者的髋关节伸肌功能障碍 症状性髋关节OA。将使用肌肉骨骼模拟和基于血清的软骨健康生物标志物 为了量化髋关节接触力和全身软骨转换/合成中发生的变化， 在机械应力测试中，这些研究结果将用于确定 臀大肌纤维化和髋伸肌扭矩发展率随髋关节负荷的变化， 有症状的髋关节OA人群中的软骨健康和自我报告的髋关节疼痛。完成此K 01后 项目，申请人将拥有所需的知识，以实现这一新的实验平台上， 评估髋关节伸肌功能障碍与髋关节OA疾病之间纵向关系的大规模基础 在随后的R 01申请中进行。 PI已经制定了一个强大的培训计划，在老化，肌肉成像，肌肉生理学和 生物化学标记物。PI已经建立了一个多元化的咨询委员会， 治疗，生物力学，肌肉生理学，OA运动，OA生物标志物和生物统计学。K01- 该奖项将为PI提供完成本项目目标所需的培训和资源，并将 领导PI走向成功的职业生涯作为一个独立的调查员在老龄化相关的研究。

Project Summary/Abstract Hip osteoarthritis (OA) impacts approximately 25% of the population over the age of 45 years. Current conservative treatments include exercise-based programs yet these interventions are ineffective in reducing hip OA-related clinical and functional abnormalities. One limitation of these exercise programs is the lack of evidence used to establish these treatment paradigms, which leads to the ineffectiveness of these programs in treating hip OA. Current experimental protocols used to inform exercise programs for the hip OA population lack precision in measuring hip joint muscular dysfunction. Therefore, there is a need to establish an experimental platform that can precisely measure hip joint muscular dysfunction. The novel experimental platform proposed in this application will be able to precisely assess hip muscle dysfunction and will provide clinicians with the evidence needed to develop effective multi-disciplinary, exercise programs for conservative treatment of symptomatic hip OA. The principal investigator (PI) of this K01 award will develop a novel, multi-modal experimental platform that will precisely measure the effects of hip extensor muscle dysfunction in patients with symptomatic hip OA. The PI will utilize novel imaging techniques and assessment of muscle torque development to assess the pathomechanism of hip extensor dysfunction in patients with symptomatic hip OA. The corresponding effects of hip extensor dysfunction during aerobic exercise (mechanical stress test) will be assessed in patients with symptomatic hip OA. Musculoskeletal simulations and serum-based biomarkers of cartilage health will be used to quantify the changes that occur in hip joint contact forces and systemic cartilage turnover/synthesis, respectively, during the mechanical stress test. These study results will be used to determine the relationship of gluteus maximus muscle fibrosis and hip extensor rate of torque development with changes in hip loading, cartilage health and self-reported hip pain in the symptomatic hip OA population. Upon completion of this K01 project, the applicant will possess the knowledge needed to implement this novel experimental platform on a large scale basis to assess the longitudinal relationship between hip extensor dysfunction with hip OA disease progression in the subsequent R01 application. The PI has developed a strong training plan in aging, muscle-imaging, muscle-physiology and biochemical biomarkers. The PI has established a diverse advisory committee with expertise in aging, physical therapy, biomechanics, muscle-physiology, exercise for OA, biomarkers of OA and biostatistics. This K01- award will provide the PI with the training and resources needed to accomplish the goals of this project and will lead the PI towards a successful career as an independent investigator in aging-related research.