Administrative Core

摘要行政核心 协作科学面临着与项目或计划的规模和范围平行的独特挑战。超出 科学挑战增加（如数据整合和协调）， 在计划增加的范围内有效地协调、沟通和协作。拟议项目包括 四个主要研究项目，由三个资源核心支持，由多元化的多学科团队执行 分布在五个研究机构。这个行政核心的目标是促进他们的 协调、沟通和协作。我们的领导团队拥有丰富的协调经验， 管理大型，多研究者项目;最值得注意的是作为体细胞的小动物测试中心 基因组编辑（SCGE）第一阶段的资金，并作为一个精密遗传学中心（JAX精密遗传学中心， JCPG）改进人类疾病的动物模型，并将其转化为临床。的每一个中 在这些项目中，我们建立了组织团队的框架， 和机构，跟踪进展和里程碑，并向主要利益相关者以及 国家卫生研究院的官员们我们以前的经验领导管理/协调核心的多- 机构，NIH资助的计划使我们唯一有资格制定和执行的行政 U19的目标管理核心将为U19计划提供管理和行政结构 通过以下目标。在目标1中，我们建立有效的行政管理结构， U19计划的成功。我们利用以往的经验和程序的具体特点，建立一个明确的 包括神经退行性疾病临床专家的指导， IND申请。在目标2中，我们制定了一个正式的会议时间表，以促进执行所需的沟通 这一提案的目标。管理核心将负责管理此时间表，记录， 报告这些会议的进展情况和确定的行动项目。管理核心将使用这些 报告，以监测该计划的里程碑和目标3的每个项目的进展情况，协助NIH计划 官员们对我们的计划与SCGE第二阶段的一致性。最后，管理核心将传达 从这个U19计划与翻译协调和传播中心的外部调查结果 分发和协助建立一个共享的学习和培训教育中心。

SUMMARY ADMINISTRATIVE CORE Collaborative science faces unique challenges that parallel the size and scope of the project or Program. Beyond increased scientific challenges (such as data integration and harmonization), so too do the challenges to coordinate, communicate, and collaborate effectively within the Program increase. The proposed project includes four major research projects, supported by three resource cores, executed by a diverse multi-disciplinary team distributed across five research institutions. The goal of this Administrative (Admin) Core is to facilitate their coordination, communication, and collaboration. Our leadership team has extensive experience coordinating and managing large, multi-investigator programs; most notably as a small animal testing center in Somatic Cell Genome Editing (SCGE) Phase I funding, and as a precision genetics center (JAX Center for Precision Genetics, JCPG) improving animal models of human disease and move them towards translation to the clinic. In each of these programs, we have established frameworks for organizing our teams, sharing information across projects and institutions, tracking progress and milestones, and communicating progress to key stakeholders as well as the NIH program officers. Our previous experience leading Administration/Coordination Cores for multi- institutional, NIH-funded Programs makes us uniquely qualified to develop and execute on the administrative goals of this U19. The Admin Core will provide managerial and administrative structure for this U19 Program through the following Aims. In Aim 1 we establish an effective administrative governance structure to assure success of this U19 Program. We use prior experience and Program-specific characteristics to build a clear hierarchy of governance and include guidance from clinical experts in neurodegenerative diseases to hasten IND application. In Aim 2 we develop a formal meeting schedule to foster the communication needed to execute on the goals of this proposal. The Admin Core will be responsible for managing this schedule, recording, and reporting out on the progress and action items identified in these meetings. The Admin Core will use these reports to monitor progress toward milestones of the Program and each Project for Aim 3, assisting NIH Program officials in their alignment of our Program with SCGE Phase II. Finally, the Admin Core will communicate the findings from this U19 Program with the Translational Coordination and Dissemination Center for external distribution and assist in the creation of a shared learning and training education hub.