Studying 24-hour rhythms of light exposure, alignment with rest-activity cycle, and cardiometabolic health in a nationally representative sample

项目摘要 昼夜节律，由内源性分子钟产生，并由光暗周期引起， 在协调与心脏代谢健康相关的许多生理和行为过程中起着核心作用。一 越来越多的证据表明，一天中不同时间的光暴露与心脏代谢结果有关， 这表明24小时光暗周期的特征可能是疾病风险的独特预测因子。然而，在这方面， 缺乏集中于全面评估24小时光暴露的研究，特别是， 它与日间行为的一致性，以了解其对人类健康的影响。一个很好的- 健康的昼夜节律计时系统的既定标志是多个生理节律的同步和适当对准。 元素之间，例如在环境刺激（例如，光-暗循环）和昼夜行为（例如，活动- 休息周期）。我们在老年男性中进行的初步研究应用相量分析来评估腕动计与腕动计之间的一致性。 测量了24小时的光暗和活动-休息周期，我们发现两者之间的受损对齐是 与糖尿病有关。这些发现表明，曝光时间的不同步 和活动模式可能是心脏代谢风险的独特预测因素，这是一个新的假设，需要 在更广泛的人群中进行测试。我们建议通过在研究中进行二级数据分析来检验这一假设。 国家健康和营养检查调查（NHANES，2011-2014），其中有24小时的详细数据， 光线和活动模式以及丰富的心脏代谢健康信息。此外，多样性和民族性 代表性样本将使我们能够确定24小时曝光模式，其相互关系， 活动-休息周期及其与心脏代谢结局的相关性可能因亚组而异， 不同的人口、社会经济和职业特征。目的1研究24- 小时光照及其与心脏代谢健康相关休息和活动模式的一致性 在NHANES的成年参与者中。在这个目标中，我们将应用参数和非参数方法， 表征明-暗周期和相量分析的多个方面，以表征 光暗和活动-休息周期，以研究它们与心脏代谢结果的关系。目标2学习灯 暴露、与休息和活动的一致性及其与成人心脏代谢健康的关系 人口、社会经济和职业属性不同的人口。为此，我们将 研究多种人口属性作为24小时明暗周期的决定因素及其与活动的一致性， 休息周期，并作为光暴露和心脏代谢健康之间的关联的调节剂。光 暴露是心脏代谢疾病的一个潜在的可改变的风险因素，我们的研究将有助于更好地 了解光暴露对心脏代谢健康和疾病差异的贡献，并提供 制定旨在控制光暴露的预防和治疗干预措施的证据， 活动-休息模式，以改善昼夜节律功能和心脏代谢健康。

PROJECT SUMMARY Circadian rhythms, generated by endogenous molecular clocks and entrained by the light-dark cycle, play a central role in orchestrating many physiological and behavioral processes related to cardiometabolic health. A growing body of evidence has linked light exposure at different times of the day and cardiometabolic outcomes, suggesting that characteristics of 24-hour light-dark cycle may be unique predictors of disease risk. However, there is a lack of investigation focusing on comprehensively assessing 24-hour light exposure, and in particular, its alignment with diurnal behavioral, to understand its health implications in human populations. A well- established hallmark of a healthy circadian timing system is the synchronization and proper alignment of multiple elements, such as between the environmental stimuli (e.g., light-dark cycle) and diurnal behaviors (e.g., activity- rest cycle). Our pilot study in older men applied phasor analysis to assess the alighnment between actigraphy- measured 24-hour light-dark and activity-rest cycles, and we found that impaired alignment between the two was associated with diabetes. These findings suggest that poor synchronization between the timing of light exposure and activity patterns may be a unique predictor of cardiometabolic risk, a novel hypothesis that needs to be tested in broader populations. We propose to test this hypothesis by conducting secondary data analysis in the National Health and Nutrition Examination Survey (NHANES, 2011-2014), which has detailed data on 24-hour light and activity patterns and rich information on cardiometabolic health. Moreover, the diverse and nationally representative sample will allow us to determine how 24-hour patterns of light exposure, its interrelationship with activity-rest cycles, and their associations with cardiometabolic outcomes may vary among subgroups with different demographic, socioeconomic, and occupational characteristics. Aim 1 Study characteristics of 24- hour light exposure and its alignment with rest and activity patterns in relation to cardiometabolic health in adult participants in NHANES. In this aim we will apply parametric and nonparametric methods to characterize multiple aspects of light-dark cycles and phasor analysis to characterize the alignment between light-dark and activity-rest cycles to study their associations with cardiometabolic outcomes. Aim 2 Study light exposure, alignment with rest and activity, and their associations with cardiometabolic health in adult populations with different demographic, socioeconomic and occupational attributes. In this aim we will examine multiple population attributes as determinants of 24-hour light-dark cycles and its alignment with activity- rest cycles, and as moderators of the association between light exposure and cardiometabolic health. Light exposure is a potentially modifiable risk factor for cardiometabolic diseases, and our study will help better understand the contribution of light exposure to cardiometabolic health and disease disparities, and provide evidence for developing preventive and therapeutic interventions aimed at manipulating light exposure and activity-rest patterns to improve circadian function and cardiometabolic health.