Research Training in Childhood Cancer

项目摘要 这位露丝·L Kirschstein国家研究服务奖博士后研究培训补助金续期 申请是根据计划公告PA-16-152提交的。这是一份更新申请， 继续提供机构T32奖，以培训将独立的年轻医生-科学家 研究人员对人类健康中的重要问题进行研究。应用程序请求 持续的资源，以支持四名医生/科学家，每年与MD或MD/博士学位谁收到 指导的研究，重点是病因，发病机制和儿科恶性肿瘤的治疗。的 这个T32计划的总体目标是培训新的调查人员，他们将改善对儿童的护理， 癌该计划的基本原理是基于美国儿童癌症的巨大负担。 有充分文件证明，迫切需要为年轻人提供有指导的职业发展支持， 这将使他们成为完全独立和富有成效的实验室研究人员。因此，在本发明中， 他们将准备通过带来最新的， 艺术专业知识，以承担的问题，如遗传倾向，环境因素，有毒和 目前治疗的相对非特异性性质，以及诱变治疗的长期不良反应。的 该计划的设计涉及利用世界级研究科学家的专业知识， 跨学科培训的导师。我们成功地为实验室实施了不同的培训轨道- 基础和临床/翻译研究者。我们认为，T32项目的进展， 成立于2007年表明，加州大学旧金山分校有远见，经验和基础设施，以培养下一个 儿童癌症研究的一代领导者。在此更新申请中，我们提供证据证明 部门或儿科和肿瘤科与更广泛的UCSF研究界一起 包括一个特殊的环境，为年轻医生作为独立的生产性职业做好准备 儿童癌症领域的研究者。本申请描述了一个全面的计划， 培训和指导这些人。该应用程序与人类健康直接相关，因为它要求 基金，以支持指导的职业发展，为优秀的年轻医生/研究人员谁将成为 儿童癌症领域的独立研究人员。像这样的项目代表了对 公共卫生的未来，因为通过该奖项培训的研究人员将能够利用国家- 最先进的研究技术来解决儿科人群中的一个可怕的健康问题。长期 这项T32奖项提供的密集和创新培训的结果将是有效的新疗法， 儿童癌症

PROJECT SUMMARY This Ruth L. Kirschstein National Research Service Award Postdoctoral Research Training Grant renewal application is submitted in response to Program Announcement PA-16-152. This is a renewal application to continue to provide institutional T32 awards to train young physician-scientists who will become independent investigators conducting research addressing important problems in human health. The application requests continued resources to support four physician/scientists each year with MD or MD/PhD degrees who receive mentored research that focuses on the etiology, pathogenesis, and treatment of pediatric malignancies. The overall objective of this T32 program is to train new investigators who will improve the care of children with cancer. The rationale for the program is based on the substantial burden of pediatric cancer in the United States and the well-documented and critical need to provide mentored career development support for young physicians that will enable them to become fully independent and productive laboratory researchers. As such, they will be poised to improve the health of children with cancer throughout the world by bringing state-of-the- art expertise to bear on problems such as inherited predispositions, environmental factors, the toxic and relatively non-specific nature of current therapies, and long-term adverse effects of mutagenic treatments. The design of this program involves harnessing the expertise of world-class research scientists who serve as mentors for interdisciplinary training. We have successfully implemented distinct training tracks for laboratory- based and clinical/translational investigators. We believe that the progress of this T32 program since its inception in 2007 demonstrates that UCSF has the vision, experience, and infrastructure to train the next generation of leaders in childhood cancer research. In this renewal application, we provide evidence that the Department or Pediatrics and Division of Oncology together with the broader UCSF research community comprise an exceptional environment for preparing young physicians for productive careers as independent investigators the field of childhood cancer. This application describes a comprehensive plan for identifying, training, and mentoring these individuals. This application is directly relevant to human health as it requests funds to support mentored career development for outstanding young physician/investigators who will become independent researchers in the field of childhood cancer. Programs like this one represent an investment in the future of public health as the researchers who are trained through this award will be equipped to harness state- of-the-art research techniques to attack a formidable health problem in the pediatric population. The long-term outcome of intensive and innovative training provided by this T32 award will be effective new treatments for childhood cancers.