Research Methods Core

研究方法核心：抽象 健康人2020呼吁进行研究并制定政策，以消除种族和民族在健康状况、健康 行为、功能限制和医疗保健使用。尽管在实现这些目标方面取得了进展， 对于美洲印第安人、阿拉斯加原住民、夏威夷原住民和太平洋岛民来说，巨大的差距仍然存在。这些 阿尔茨海默病和相关痴呆症的风险因素患病率较高，且 这些疾病诊断不足的风险高于其他人群。因此，当地人患有阿尔茨海默氏症 研究中心将在年内开展以社区为基础的阿尔茨海默病和相关痴呆症研究 美国印第安人、阿拉斯加原住民、夏威夷原住民和太平洋岛民使用方法和 产生准确、可靠数据的仪器。研究方法核心的主要功能是协作 与单个研究项目和核心共享专业知识，以提高每个研究项目和核心的科学功能 中心的组件。为了取得成功，我们的研究项目和核心需要创新的设计， 可衡量、可实现的目标；有效的资源分配；适当的执行；经常、 有意义的评价；以及适当的统计分析。因此，研究方法的核心目标 是通过标准化测量和分析方法来最有效地利用研究资源 尽可能优化内部和外部研究的有效性；并确保推理的相关性 针对医疗保健提供者、政策制定者、社区领袖和其他关键利益相关者的分析。研究报告 方法核心的具体目标是：1)与每个RP团队和其他核心集成，以提供最新的 ART对样本量和能量计算、研究设计、抽样和实施的方法学支持； 并主动确定在研究项目团队和 核心以及跨研究协作；2)通过a)最大限度地提高研究项目的科学有效性) 确保研究措施的可靠性和有效性；b)标准化测量、数据收集、 和数据库设计；c)确保研究的重复性和透明度 项目结果；以及3)采用灵活而全面的定量和定性数据分析策略， 利用跨学科研究方法核心教师专业知识实施最具可重复性的 对每个研究项目的具体目标进行分析。核心将最大限度地提高科学严谨性，同时容纳 在现实世界的研究工作中出现的后勤和方法挑战。它将利用 具有多年多项目赠款工作经验的方法学家的技能，以及许多现有的 合伙企业。研究方法核心、研究项目和核心之间的协作将发挥 在确保我们的工作有助于了解和改善阿尔茨海默氏症和 美洲印第安人、阿拉斯加原住民、夏威夷原住民和太平洋岛民之间的相关痴呆症差异。

RESEARCH METHODS CORE: ABSTRACT Healthy People 2020 calls for research and policy to eliminate racial and ethnic disparities in health status, health behaviors, functional limitations, and healthcare use. Although progress has been made toward these goals, large disparities persist for American Indians, Alaska Natives, Native Hawaiians, and Pacific Islanders. These groups have a high prevalence of risk factors for Alzheimer’s disease and related dementias and are at greater risk than other groups for under diagnosis of these disorders. Accordingly, the Natives Engaged in Alzheimer’s Research Center will conduct community-based Alzheimer’s disease and related dementias studies within American Indian, Alaska Native, Native Hawaiian, and Pacific Islander populations using methods and instruments that yield accurate, reliable data. The Research Methods Core’s primary function is to collaborate with individual Research Projects and Cores, sharing expertise to improve the scientific function of each component of the Center. To be successful, our Research Projects and Cores require innovative designs with measurable, achievable objectives; efficient resource allocation; appropriate implementation; regular, meaningful evaluations; and appropriate statistical analyses. Accordingly, the Research Methods Core’s goals are to make the most efficient use of study resources by standardizing methods for measurement and analysis to the extent possible; to optimize internal and external study validity; and to ensure the relevance of inferential analyses for healthcare providers, policymakers, community leaders, and other key stakeholders. The Research Methods Core’s Specific Aims are to: 1) Integrate with each RP team and other Cores to provide state-of-the- art methodological support for sample size and power calculations, study design, sampling, and implementation; and proactively identify opportunities for disseminating best practices between Research Project teams and Cores, as well as for cross-study collaboration; 2) Maximize the scientific validity of the Research Projects by a) ensuring reliability and validity of study measures; b) standardizing methods for measurement, data collection, and database design to the extent possible; and c) ensuring the reproducibility and transparency of Research Project results; and 3) Apply a flexible and comprehensive quantitative and qualitative data analytic strategy that leverages transdisciplinary Research Methods Core faculty expertise to implement the most reproducible analyses for each Research Project’s Specific Aims. The Core will maximize scientific rigor while accommodating the logistical and methodological challenges that arise in real-world research endeavors. It will leverage both the skills of methodologists with years of experience working on multi-project grants, as well as numerous existing partnerships. The collaboration between the Research Methods Core, Research Projects, and Cores will play a critical role in ensuring that our work contributes to understanding and ameliorating Alzheimer’s disease and related dementias disparities in American Indians, Alaska Natives, and Native Hawaiians, and Pacific Islanders.