Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation

摘要 在杜克大学超级基金研究中心(DUSRC)内进行的研究将研究 早期接触多环芳烃和金属对神经发育健康的影响。金属(特别是铅)和 在Superfund和Brownfield网站上，PAHs都是确定的十大污染物之一，而且它们经常与 发生。因此，接触到这些污染物的混合物是非常常见的。不幸的是， 经常受到这些暴露影响的社区是有色人种，这可能会进一步 与美国日益扩大的健康差距有关。尽管它们同时发生，但对它们的风险的评估 通常会忽视联合暴露的影响。因此，站点管理策略通常试图将 多污染物问题，导致基于与单一污染物相关的健康风险的补救目标 曝光，而不是现实世界的混合。我们在DUSRC的首要目标是调查共同暴露 正如NIEHS促进环境健康的战略计划所描述的那样，这是“复制人类经验” 科学。更具体地说，我们的中心将研究多种污染物暴露对人类和 神经发育健康的生态模型，阐明了这些共同作用产生的神经毒性机制 暴露，并制定针对最高风险污染物的补救和处理战略 增加了其他污染物的风险。这一整合是评估暴露于 危险物质。DUSRC通过调查对健康的影响来直接解决该计划的任务 以及以跨学科的方式对危险物质进行风险和补救。我们的跨学科团队 毒物学家、暴露科学家、环境化学家、工程师、流行病学家和社区 环境管理人员，为DUSRC提供了一个独特的机会来处理和检查这个综合体 使用系统方法的问题。除了回应SRP的任务外，DUSRC的研究， 研究翻译和社区参与活动也与许多利益相关者高度相关 在地方、地区和联邦各级。我们的工作将提供需要解决的关键数据和信息 与超级基金研究计划相关的几个问题。

Abstract Research conducted within the Duke University’s Superfund Research Center (DUSRC) will study neurodevelopmental health impacts of early-life co-exposures to PAHs and metals. Metals (particularly Pb) and PAHs are among the top 10 contaminants identified at both Superfund and Brownfield sites, and they often co- occur. Therefore, exposure to mixtures of these contaminants is very common. And unfortunately, the communities that are often more impacted by these exposures are people of color, which can further contribute to the growing health disparities in the United States. Despite their co-occurrence, evaluations of their risks typically neglect the impacts of co-exposures. As a result, site management strategies often try to discretize the multi-contaminant problem, leading to remediation targets that are based on health risks associated with a single exposure rather than real-world mixtures. Our overarching goal within the DUSRC is to investigate co-exposures that “replicate the human experience”, as described by NIEHS’s Strategic Plan to advance environmental health science. More specifically, our Center will study the impacts of multiple contaminant exposures in humans and ecological models of neurodevelopmental health, elucidate neurotoxic mechanisms that occur from these co- exposures, and develop remediation and treatment strategies that target the highest risk contaminants without increasing the risk of other contaminants. This integration is central to evaluating the true risk from exposure to hazardous substances. The DUSRC directly addresses the program mandates by investigating health effects and risks and remediation of hazardous substances in an interdisciplinary fashion. Our interdisciplinary team of toxicologists, exposure scientists, environmental chemists, engineers, epidemiologists, and community based environmental managers, provide the DUSRC with a unique opportunity to address and examine this complex problem using a systems approach. In addition to responding to SRP mandates, the DUSRC’s research, research translation, and community engagement activities are also highly relevant to numerous stakeholders at the local, regional and federal levels. Our work will provide key data and information needed to address several problems relevant for the Superfund Research program.