Core L - Clinical & Behavioral Sciences Core

项目摘要/摘要 Corel：临床和行为科学核心 普罗维登斯/波士顿艾滋病研究中心(Prov/Bos CFAR)临床和行为科学核心 (CBSC)(前身为生物行为科学核心)支持创新的临床和行为研究， 单独或协调一致，这对改善艾滋病毒治疗和预防工作的结果至关重要 瀑布。这种方法使我们站在了转化科学的前沿，使有效的艾滋病毒 将治疗和预防干预纳入现实世界的环境。核心支持的研究涉及 弱势群体，包括非裔美国人/黑人和西班牙裔/拉丁裔社区；同性恋、双性恋和 其他男男性行为者(MSM)；艾滋病毒和结核病合并感染或疾病的人； 伸张正义的个人；妇女；青少年和年轻人；以及生活在高度流行病中的人 资源受限设置。我们多样化的临床和行为服务在五个领域支持艾滋病毒研究，并 包括我们的目标：1)向艾滋病毒携带者和艾滋病毒感染风险人群提供机会， 包括相关数据。这包括为参与者招募、登记和保留提供支持，以 推进临床和行为研究；2)提供服务，支持创新的临床和行为数据 收集方法，包括方法、工具和评估；3)提供与以下方面相关的专业知识和服务 监管和人类受试者的遵从性，以及对弱势群体进行研究的道德行为；4) 提供专业知识和服务，以支持制定、实施和评估干预措施 改善艾滋病毒预防和持续护理成果；以及5)提供专门服务 实施科学研究，以及进行成本效益研究。创新的例子 由我们的核心支持的临床和行为研究包括探索长效注射ART的使用 和PrEP，以及解决南方腹地艾滋病毒护理和预防差距的工作。其他创新包括 一种理论驱动的方法，通过促进新的网络，扩大CFAR对艾滋病毒科学的影响 该地区、城市和受严重影响的州之间以及国际地点。核心联席董事，关键 核心学院和核心经理拥有提供所提供服务所需的技能和专业知识。这个 CBSC教职员工审查现有项目，集思广益新研究想法，促进新研究 协作，促进使用可用的数据集和存储库样本，并探索开发 兼容的跨站点数据集。CBSC是Prov/Bos CFAR总体任务的核心， 促进和支持针对美国国立卫生研究院艾滋病研究办公室优先领域的临床和行为研究。

PROJECT SUMMARY/ABSTRACT CoreL: CLINCAL AND BEHAVIORAL SCIENCES CORE The Providence/Boston Centers for AIDS Research (Prov/Bos CFAR) Clinical and Behavioral Sciences Core (CBSC) (formerly the BioBehavioral Sciences Core) supports innovative clinical and behavioral research, individually or in concert, which are critical to improving outcomes along the HIV treatment and prevention cascades. This approach has positioned us at the forefront of translational science to move efficacious HIV treatment and preventive interventions into real-world settings. Research supported by the Core involves vulnerable populations, including African American/Black and Hispanic/Latino communities; gay, bisexual and other men who have sex with men (MSM); people with HIV and tuberculosis co-morbid infection or disease; justice-involved individuals; women; adolescents and young adults; and persons living in hyperepidemic resource-limited settings. Our diverse clinical and behavioral services support HIV research in five areas and comprise our aims: 1) provide access to populations of persons with HIV and persons at risk for HIV infection, including associated data. This includes support with participant recruitment, enrollment, and retention to advance clinical and behavioral research; 2) provide services to support innovative clinical and behavioral data collection approaches, including methods, tools, and assessments; 3) provide expertise and services related to regulatory and human subjects’ compliance, and the ethical conduct of research for vulnerable populations; 4) provide expertise and services to support the development, implementation, and evaluation of interventions to improve HIV prevention and continuum of care outcomes; and 5) provide specialized services for the conduct of implementation science research, as well as performing cost-effectiveness research. Examples of the innovative clinical and behavioral research supported by our Core include exploring the use of long-acting injectable ART and PrEP, and work addressing HIV care and prevention disparities in the Deep South. Other innovations include a theory-driven approach that extends the influence of CFAR on HIV science by facilitating new networks across the region, between cities and heavily-impacted states, and in international sites. The Core Co-Directors, Key Core Faculty, and Core Manager have the requisite skills and expertise to provide the services offered. The CBSC faculty and staff review existing projects, brainstorm new research ideas, foster new research collaborations, promote the use of available datasets and repository specimens, and explore the development of compatible cross-site datasets. The CBSC is central to the overall mission of the Prov/Bos CFAR and promotes and supports clinical and behavioral research addressing NIH Office of AIDS Research priority areas.