Pilot Projects and Trans-Network Activities

摘要 该试点项目计划(PPP)在经过外部审查和申请者与 UTPDTC高级调查人员，一个灵活、灵活的平台，为有潜力的新研究提供种子资金 对PDX和药物开发研究产生重大影响。我们有以下具体目标：1.提供 购买力平价资助侧重于PDX和药物开发研究的项目。2.利用MDACC的专业知识和 UTSW科学和临床领导者以及PDXNet研究人员和核心领导者确定高影响的PDX 以及UTMDACC、UTSW、PDXNet和相关环境中的药物试点项目。3.在良好的基础上- 在UTMDACC和UTSW建立了指导和整合PDXNet调查人员的机制， 项目和核心。4.建立在现有的PDXNet框架上，以促进基本和 UTMDACC和UTSW内外的临床科学家，跨学科，并指导新的 一代PDX和药物开发研究人员。5.促进这些领域的发展和过渡 将成功的项目转化为具有竞争力的同行评审资金申请。6.在现有PDXNet的基础上构建 将这些发现转化为临床的机制。试点项目和跨网络活动核心将相互影响 与其他网络单位共同开发跨网络协作项目，并将协助非 NCI选择参加PDXNet的网络调查人员。我们将与 在共享有关PDX人口统计的数据方面，PDCCC PDX数据共享和协调中心 信息、分子特征和对试剂的响应，以及共同开发数据分析方法。

Abstract This Pilot Projects Program (PPP) provides, after selection by external review and applicant discussion with senior UTPDTC investigators, a flexible and nimble platform for seed funding of novel research that has potential to significantly impact PDX and drug development research.We have the following Specific Aims: 1. Provide PPP funding to projects focused on PDX and drug development research. 2. Use the expertise of MDACC and UTSW scientific and clinical leaders and PDXNet investigators and Core leaders to identify high impact PDX and drug pilot projects in the UTMDACC, UTSW, PDXNet, and related environments. 3. Build on well- established mechanisms at UTMDACC and UTSW for mentorship of and integration with PDXNet investigators, Projects, and Cores. 4. Build on the existing PDXNet framework to promote communication between basic and clinical scientists, within and outside UTMDACC and UTSW, across disciplines, and guide the training of a new generation of PDX and drug development researchers. 5. Facilitate development and transition of these successful projects into competitive applications for peer-reviewed funding. 6. Build on existing PDXNet mechanisms to translate the findings into the clinic. Pilot Projects and Trans-Network Activities Core will interact with other Network units in the development of trans-Network collaborative projects, and will also assist non- Network investigators chosen to participate in PDXNet by NCI. Close interaction will be maintained with the PDCCC PDX Data Commons and Coordinating Center in terms of sharing data regarding PDX demographic information, molecular characterization and response to agents, and jointly developing methods to analyze data.