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Signaling by Chondroitin Sulfate Proteoglycans

Signaling by Chondroitin Sulfate Proteoglycans
硫酸软骨素蛋白多糖发出的信号
批准号：
10699709
负责人：
HERBERT M. GELLER
金额：
$83.4万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10699709
关键词：
AdhesionsAffectAnimal ModelAstrocytesCentral Nervous SystemChondroitin Sulfate ProteoglycanCicatrixCore ProteinCytoskeletonGoalsGuanosine Triphosphate PhosphohydrolasesInjuryInvestigationMembraneModificationNatural regenerationNerve RegenerationNeuronal PlasticityNeuronsPaperPeptide HydrolasesPhosphoric Monoester HydrolasesProcessPropertyProteinsPublishingReceptor ActivationRoleSignal TransductionSitechondroitin sulfate glycosaminoglycanexperimental studyextracellularinorganic phosphatelipid phosphate phosphatasereceptorrhoB p20 GDIsugar

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中文摘要
翻译
我们证明了脂质磷酸磷酸酶相关蛋白（PLPPRs）可以通过与RhoGDI的相互作用来调节RhoA和Rac1 gtpase，从而调节神经元粘附和细胞骨架。描述这些结果的论文已经发表。
英文摘要
We demonstrated the the Lipid Phosphate Phosphatase-Related Proteins (PLPPRs) can modulate neuronal adhesion and the cytoskeleton through interactions with RhoGDI that modulated both RhoA and Rac1 GTPases. Papers describing these results have been published. PLPPRs, like many transmembrane receptors, are cleaved at an extracellular site near the membrane. We have now demonstrated that this cleavage is through a furin-like protease. The cleavage releases a fragment of the original receptor that associates with other transmembrane molecules. In addition, we showed that this cleavage can be regulated. Further experiments will determine the exact role of cleavage in modulating signal transduction.
期刊论文(21)
专著(0)
科研奖励(0)
会议论文
The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules.
DOI： 10.1111/jnc.15271
发表时间： 2021-05
期刊： Journal of neurochemistry
影响因子： 4.7
作者： [Agbaegbu Iweka C, Hussein RK, Yu P, Katagiri Y, Geller HM]
通讯作者： Geller HM
Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation.
DOI： 10.1002/glia.23482
发表时间： 2018-11
期刊： Glia
影响因子： 6.2
作者： [Singh K, Han K, Tilve S, Wu K, Geller HM, Sack MN]
通讯作者： Sack MN
Global analysis of neuronal phosphoproteome regulation by chondroitin sulfate proteoglycans.
DOI： 10.1371/journal.pone.0059285
发表时间： 2013
期刊： PloS one
影响因子： 3.7
作者： [Yu P, Pisitkun T, Wang G, Wang R, Katagiri Y, Gucek M, Knepper MA, Geller HM]
通讯作者： Geller HM
Effect of chondroitin sulfate proteoglycans on neuronal cell adhesion, spreading and neurite growth in culture.
硫酸软骨素蛋白聚糖对培养物中神经元细胞粘附、扩散和神经突生长的影响。
DOI： 10.4103/1673-5374.226398
发表时间： 2018-03
期刊： Neural regeneration research
影响因子： 6.1
作者： [Jin J, Tilve S, Huang Z, Zhou L, Geller HM, Yu P]
通讯作者： Yu P
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