The ANTIDOTE Institute- Advancing New Toxicology Investigators in Drug abuse and Original Translational research Efforts

项目摘要/ABSRACT 这项建议响应PAR-21-320，有两个首要目标：1)在 研究方法和假设驱动的研究；2)培养多样化的临床医学干部 毒理学家作为物质使用障碍(SUD)和公众交叉点的独立研究人员 健康。SUD的流行迫切需要研究人员之间的创新和多样性。医疗 毒理学是一个医学领域，致力于评估和治疗中毒患者，包括 毒品和非法物质对健康的不利影响。医学毒理学家在创新方面有着良好的记录 和南加州与公共卫生相关的研究；然而，很少有人追求独立的、由联邦政府资助的职业 调查人员。为了应对我们专业上的这一差距，我们与美国 医学毒理学院，一项混合研究指导计划，解毒剂(新进展) 药物滥用和原创翻译研究中的毒理学研究人员)研究所。解药 该研究所为医学毒物学家提供系统的研究方法培训和指导， 发展医疗毒理学内科科学家管道的长期目标，实现独立 联邦政府对南德研究的资助。此R25建议通过将我们的课程扩展为 更严格的培训经验，提供种子资金，加快南加州大学学院研究员的进度 研究，并扩大研究所的活动，以包括外联和多代人的指导。这个 扩展的两年期解毒剂课程将使用混合方法提供，包括面对面 务虚会、虚拟小组会议/授课和虚拟一对一会议。我们已经集结了一支强大的多 是研究方法方面的专家、南加州大学管理的创新者和硕士的学科教员 教育工作者。这项建议的具体目标是：1)扩大、实施和广泛宣传 解药研究所，其课程以参与式学习理论为基础，以支持 毒理学家作为临床科学家：2)使用经过验证的 方案评价工具：和3)促进和维持发展多样化的调查员渠道 通过指导技能、知识转化和外展等方面的培训，提供医疗毒理学。安蒂奥德 研究所是第一个系统地解决医学毒理学教育空白的同类项目。 围绕开发假设驱动的研究调查进行培训。该计划的成功扩展将 促进对SUD的方法严谨和临床知情的研究，并创建一个全国性的 不同的调查人员来维持这一势头。然后，可以将此框架翻译到 医疗毒理学，以促进其他临床专科的流水线开发。

PROJECT SUMMARY/ABSRACT This proposal is responsive to PAR-21-320 with two overarching goals: 1) to provide empiric training in research methodology and hypothesis-driven research, and 2) to train a diverse cadre of clinical medical toxicologists as independent researchers at the intersection of substance use disorder (SUD) and public health. The epidemics of SUD are in sore need of innovation and diversity among researchers. Medical Toxicology is a field of medicine dedicated to the evaluation and treatment of poisoned patients, including adverse health effects of drugs and illicit substances. Medical toxicologists have a track record of innovation and public health-relevant research in SUD; however, few pursue careers as independent, federally funded investigators. In response to this gap in our specialty, we developed in collaboration with the American College of Medical Toxicology, a hybrid research mentorship program, the ANTIDOTE (Advancing New Toxicology Investigators in Drug abuse and Original Translational research Efforts) Institute. The ANTIDOTE Institute provides structured research methodology training and mentorship to medical toxicologists with a long-term goal of developing a pipeline of medical toxicology physician scientists that achieve independent federal funding in SUD research. This R25 proposes to formalize ANTIDOTE by extending our curriculum for a more rigorous training experience, providing seed funding to accelerate the progress of institute fellows in SUD research, and expanding institute activities to include outreach and multi-generational mentorship. The expanded two-year ANTIDOTE curriculum will be delivered using a hybrid approach including in-person retreats, virtual group meetings/didactics, and virtual one-on-one meetings. We have assembled a strong multi- disciplinary faculty who are experts in research methodology, innovators in the care of SUD, and master educators. The Specific Aims of this proposal are: 1) To expand, implement and widely disseminate the ANTIDOTE institute with a curriculum grounded in Participatory Learning Theory to support the development of toxicologists as clinician scientists: 2) To evaluate the impact of the ANTIDOTE institute using a validated program evaluation tools: and 3) To facilitate and sustain the development of a diverse investigator pipeline in medical toxicology, through training in mentorship skills, knowledge translation and outreach. The ANTIODTE Institute is the first program of its kind to systematically address educational gaps within medical toxicology training around developing hypothesis-driven research investigations. Successful expansion of the program will facilitate methodologically rigorous and clinically informed research on SUD and create a national network of diverse investigators to sustain this momentum. This framework can then be translated outside of the field of medical toxicology to facilitate pipeline development in other clinical specialties.