Pilot Projects

设计了生物分子结构与动力学中心(CBSD COBRE)的试点项目方案 为初级调查人员的研究计划提供种子，并向现有调查人员提供资金，以 将他们的研究项目推向新的方向。该计划建立在类似计划的成功基础上 在CBSD Cobre第一和第二阶段期间实施。在前几个阶段资助的28个试点项目 Cobre的支持导致了32项赠款奖励，为CBSD带来了总计1550万美元的资金 调查人员。试点项目方案还导致使用四个由科布雷支持的 研究核心和相关充值收入的增加。我们将继续刺激经济增长 通过分配Cobre和机构资金来提供CBSD研究资金和使用我们的研究核心 维持这一有价值的计划。与Cobre支持的第一阶段和第二阶段一样，我们将使用试点项目计划来 为初级调查员的职业生涯提供种子(具体目标1)，并协助老牌调查员寻求新的 研究方向(具体目标2)。为了扩大这个项目对我们研究增长的影响 在第三阶段，为了增强我们的研究中心的能力，我们还将优先考虑试点 涉及多PI协作的项目(具体目标3)或推动新核心的开发 技术(具体目标4)。前者将使赠款申请的发展具有强大的 后者将有助于使我们的研究核心保持在技术前沿。至关重要的是 我们的试点项目计划的成功将是有效的指导计划(特定目标5)，例如 水赠书写作工作坊。我们将继续完善试点计划，评估其 成效与我们外部咨询委员会的年度投入，以便我们能够最大限度地发挥其对 我们的研究努力。为增加研究经费而实施的试点项目的良好记录 和CBSD调查人员的生产力以及推动我们研究核心的技术发展是一个关键 这是我们战略计划的组成部分，目的是在Cobre提供第三阶段资金后维持CBSD。

The Pilot Project program of the Center for Biomolecular Structure and Dynamics (CBSD) COBRE is designed to seed the research programs of junior investigators and to provide established investigators with funding to move their research programs in new directions. This program builds on the success of a similar program implemented during phases I and II of the CBSD COBRE. The 28 Pilot Projects funded during previous phases of COBRE support led to 32 grant awards that brought in a total of $15.5 million of funding to CBSD investigators. The Pilot Project program also led to a large increase in the use of the four COBRE-supported research cores and an associated increase in recharge income. We will continue to stimulate the growth of CBSD research funding and the use of our research cores by allocating COBRE and institutional funds to sustain this valuable program. As in phases I and II of COBRE support, we will use the Pilot Project program to seed the careers of junior investigators (specific aim 1) and to assist established investigators in pursuing new research directions (specific aim 2). To expand the impact of this program on the growth of our research enterprise and to enhance the capabilities of our research cores during phase III, we also will prioritize Pilot Projects that involve multi-PI collaborations (specific aim 3) or drive the development of new core technologies (specific aim 4). The former will allow for the development of grant submissions with a strong competitive edge and the latter will help to keep our research cores at the technological forefront. Critical to the success of our Pilot Project program will be effective mentoring programs (specific aim 5), such as the Hot Water grant writing workshop. We will continue to improve the Pilot Project program by evaluating its effectiveness with annual input from our External Advisory Committee so that we can maximize its impact on our research endeavors. The proven track-record of the Pilot Project program to increase the research funding and productivity of CBSD investigators and to drive technological development in our research cores is a key element of our strategic plan to sustain the CBSD after phase III COBRE funding.