Transdisciplinary Research in Energetics and Cancer (TREC) Training Grant

摘要 鉴于肥胖症、不良饮食和缺乏运动的患病率不断上升，这些因素结合在一起被称为“能量 平衡“或”能量学“，以及它们与癌症发病率和死亡率的关系，创新研究， 需要对科学家进行临床护理和培训，以降低这些危险因素的患病率，进而降低 癌症发病率和死亡率。2020年9月，NCI发布了2022财年预算 该提案将肥胖症和癌症作为一个专题科学话题，并培训下一代 癌症研究人员作为一项关键投资。在2016-2021年的NCI R25支持下，我们开发并提供了 每年为期一周的能源与癌症跨学科研究(TREC)培训课程， 随后是一项为期一年的指导计划，重点是能量平衡和全球癌症研究 癌症控制连续体。该计划的总体目标是及早教育、培训和指导100人 职业研究人员，称为TREC研究员，来自不同的学术背景(即基础、临床和 人口科学)在能量学和癌症方面的跨学科研究。在TREC的头四年， 我们录取并培训了来自57个不同机构的97名研究员。我们正处于TREC计划的第五个年头 预计将再招聘20名研究员，总计117名完成TREC培训计划的研究员。 TREC研究员在同行评议期刊上发表了270篇手稿，其中62篇已发表手稿 包括作为第一作者或高级作者的TREC研究员，以及作为合著者的TREC学院和/或研究员。 自完成该计划以来，TREC研究员已作为首席研究员获得了31笔校外补助金。 在过去五年的优势基础上发展，但应对更多的培训和 进一步传播课程，我们的竞争更新的目标是：1)提供混合TREC 在面对面研讨会之前，采用虚拟TREC教员主导计划的培训计划，重点是 增加内容知识；2)随后举行为期5天的面对面研讨会，重点是研究员的研究， 网络和专业发展；以及3)院士和院系之间为期一年的指导 导师和同伴导师。由梅琳达·欧文博士领导，并利用耶鲁大学公共学院的资源 健康，耶鲁大学癌症中心，来自全国各地的约20名专家TREC学院和100多名TREC研究员 来自世界各地的校友，我们的TREC项目是创新的，因为目前没有培训机会 专注于能量学和癌症研究。我们的目标是继续TREC培养科学家的使命 培养一支训练有素、多样化的研究队伍。该计划的总体影响将由以下方面定义 TREC研究员产生创新研究方法和发现的程度，从而 加快将循证方法传播和实施到日常实践和 患者护理，进而改善癌症高危人群和癌症幸存者的健康。

Abstract Given the rising prevalence of obesity, poor diet and physical inactivity, known in combination as “energy balance” or “energetics”, as well as their associations with cancer incidence and mortality, innovative research, clinical care and training of scientists are needed to lower the prevalence of these risk factors and in turn, lower cancer incidence and mortality rates. In September 2020, the NCI released its Fiscal Year 2022 Budget proposal, which includes obesity and cancer as a featured scientific topic and training the next generation of cancer researchers as a key investment. With NCI R25 support from 2016-2021, we developed and offered an annual one-week, in-residence Transdisciplinary Research in Energetics and Cancer (TREC) Training Course, followed by a yearlong mentoring program, that focused on energy balance and cancer research across the cancer control continuum. The overall goals of this Program were to educate, train and mentor 100 early career investigators, called TREC Fellows, from diverse academic backgrounds (i.e., basic, clinical and population sciences) in transdisciplinary research in energetics and cancer. For the first four years of TREC, we admitted and trained 97 Fellows from 57 different institutions. We are in our 5th year of our TREC Program and expect to recruit 20 more Fellows, for a total of 117 Fellows completing the TREC Training Program. TREC Fellows have published 270 manuscripts in peer-reviewed journals, with 62 published manuscripts including the TREC Fellow as first or senior author and including a TREC Faculty and/or Fellow as co-author. Since completing the Program, TREC Fellows have received 31 extramural grants, as principal investigator. Building upon the strengths of the previous five years but responsive to additional opportunities for training and further dissemination of the course, the goals of our competitive renewal are: 1) to offer a hybrid TREC Training Program with virtual TREC Faculty-led programs before the in-person workshop focused on increasing content knowledge; 2) followed by a 5-day in-person workshop focused on the Fellows’ research, networking and professional development; and 3) year-long mentorship between the Fellow and Faculty Mentor and Peer Mentor. Led by Dr. Melinda Irwin and drawing from the resources of the Yale School of Public Health, Yale Cancer Center, and ~20 expert TREC Faculty from across the country and 100+ TREC Fellow alumni from around the world, our TREC Program is innovative in that currently no training opportunity exists that focuses on energetics and cancer research. Our goal is to continue the TREC mission of training scientists to develop a cadre of well-trained, diverse researchers. The overall impact of this program will be defined by the degree to which TREC Fellows produce innovative research approaches and discoveries, thereby accelerating the dissemination and implementation of evidence-based approaches into everyday practice and patient care, in turn improving the health of the population at risk for cancer as well as cancer survivors.