Scalable Molecular Pipelines for FAIR and Reusable BICAN Molecular Data

项目总结 该项目将创建可扩展的资源，这将是开发大脑倡议细胞图谱的关键 网络(BICAN)联盟脑图集。这个团队将专注于共同分子的开发 云本地且公平的数据处理管道。从已经建立的 BICCN管道和社区关系在以前的资金中建立，这一投资组合将得到更新和 在与比肯社区的合作下扩展。利用和改进现有的 BICCN分子(NEMO)档案和云计算环境(Terra)，该团队将处理数据 集合，由比肯社区优先考虑，并支持对地图集建设的联合分析。这些管道将 使用全面的指标面板生成数据，我们的团队将利用这些数据来执行质量控制和 确保数据处理和使用的严谨性。该小组将与分析小组合作，确认 管道与下游分析兼容，并被扩展以包含关键的下游步骤 随着它们的成熟，并得到比肯社区的同意。它所使用的云计算环境 团队将向Bcan社区开放，并由帮助台、文档、 论坛和年度讲习班。由于该基础设施横跨多个研究所，Terra目前正在启用BICCN 工作组在一个共同的可扩展空间中共享云资源和联合分析数据；这将 在比肯社区中仍然是这样的。为了实现数据的可视化、共享和发布，该团队 带来云编程环境(Terra)、专用可扩展资源(Cirrocumulus、Pegasus)和 将在联合体活动中利用的出版物门户(NEMO Analytics和Single Cell门户)。这些 共同资源将是使Bcan社区能够走到一起并执行以下分析的关键 根据比肯地图集建设工作的需要进行调整。

PROJECT SUMMARY This project will create scalable resources that will be critical to the development of BRAIN Initiative Cell Atlas Network (BICAN) consortium brain atlases. This team will focus on the development of common molecular data processing pipelines that are cloud-native and FAIR. Starting with an already established portfolio of BICCN pipelines and community relationships developed in previous funding, this portfolio will be updated and extended in collaboration with the BICAN community. Leveraging and improving existing integration between the BICCN molecular (NeMO) archive and cloud-computing environment (Terra), this team will process data sets, prioritized by the BICAN community and in support of joint analysis for atlas building. These pipelines will produce data with a comprehensive panel of metrics that our team will leverage to perform quality control and assure rigor in data processing and use. This team will work with analysis groups to confirm outputs of the pipelines are compatible with downstream analysis and are extended to incorporate critical downstream steps as they mature and are agreed upon by the BICAN community. The cloud computing environment used by this team will be open and available to the BICAN community and supported by a helpdesk, documentation, forums, and an annual workshop. As this infrastructure spans institutes, Terra is currently enabling BICCN working groups to share cloud resources and jointly analyze data in a common scalable space; this will continue to be true in the BICAN community. To enable visualizing, sharing and publishing of data, this team brings cloud programming environments (Terra), specialized scalable resources (Cirrocumulus, Pegasus), and publication portals (NeMO Analytics, and the Single Cell Portal) to be leveraged in consortium activities. These common resources will be critical to enable the BICAN community to come together and perform analysis that scales to the needs of BICAN atlas building efforts.