Clinical Translation Core

项目摘要 临床翻译核心(CTC)的总体目标是高效和有效地移动 对人类的基本和应用智力和发育障碍研究(IDDR)结果 临床研究和最终的临床实践。反恐委员会的设计是作为一个“一站式-- 为国际直拨电话调查人员提供直接或合作的协助和服务 与其他机构资源(特别是临床和翻译科学奖 (CTSA计划)在临床和转化性研究(CTR)谱的每个阶段 CNH、GW、GU、HU。这包括深入的表型、招聘、绩效、分析、 实施、商业化和传播。拟议的反恐委员会将得到协调 通过具有成本效益并提供特定基础设施支持的管理结构 DC-IDDR调查人员和他们的团队。反恐中心的直接职能将包括：1)数据 挖掘大型真实世界证据数据来源(信息学)；2)患者招募和研究 多个地点的业绩；3)在生物统计/信息学方面的咨询支持 规划、设计和分析iDDR研究；4)与其他机构的联系和合作 用于深入表型/基因分型和生物银行的IDDRC核心，以及5)培训和 通过基于网络的调查员工具包进行传播。具体目标是：1)建设一个 具有数字平台的表型组学框架，该数字平台集成了临床和组学数据以及 伙伴生物信息库；2)采用多维策略提升参与者 招聘和研究实施/绩效；3)提供与iDDR相关的研究设计； 生物统计和信息学支持；以及4)开发iDDR调查员工具包。

Project Summary The overall goal of the Clinical Translational Core (CTC) is to efficiently and effectively move basic and applied intellectual and developmental disability research (IDDR) findings into human clinical studies and ultimately clinical practice. The CTC is designed to serve as a “one-stop- shop” for IDD investigators, providing assistance and services either directly or in collaboration with other institutional resources (especially the Clinical and Translational Science Award (CTSA) program) at each stage of the clinical and translational research (CTR) spectrum at CNH, GW, GU and HU. This includes deep phenotyping, recruitment, performance, analysis, implementation, commercialization and dissemination. The proposed CTC will be coordinated by an administrative structure that is cost effective and provides specific infrastructure supports for DC-IDDR investigators and their teams. The direct functions of the CTC will include: 1) data mining of large real-world evidence data sources (informatics); 2) patient recruitment and study performance across multiple venues; 3) consultative support in biostatistics/informatics for planning, designing, and analyzing IDDR studies; 4) connection and collaboration with other IDDRC cores for deep phenotyping/genotyping and bio banking, and 5) training and dissemination through a web based investigator toolkit. The specific aims are: 1) To build a phenomics framework with a digital platform that integrates clinical and 'omics' data and a companion biorepository; 2) To employ a multi-dimensional strategy to enhance participant recruitment and study implementation/performance; 3) To provide IDDR-relevant study design, biostatistical and informatics support; and 4)To develop an IDDR investigator toolkit.