Multiscale Biophotonics: A Platform for Interdisciplinary Biomedical Research Training and Career Development

项目总结 IPERT计划的总体目标和具体目标是：(1)为学员做好以下准备 成功的多学科生物光子学职业生涯，并支持生物医学劳动力发展。这将是 通过(2)多尺度提高学员的技术和操作能力来实现 生物光子学通过整合建模、计算、实验和基于问题的学习，以及 (3)为学员提供持续的专业发展导师。这将会实现的 通过在多尺度生物光子学领域建立基础技术和操作技能 加州大学欧文分校为期12天的现场短期课程。这一为期12天的短期课程利用了 综合模块设计和循证学习，包括(A)讲座、(B)技术 演示，(C)将动手数据获取与计算分析相结合的实验室使用我们的 定制虚拟组织模拟器(VTS)软件平台，(D)团队科学培训，(E)有指导的Capstone 以问题为基础的学习(PBL)建议的制定；(F)关于跨学科使用的客座讲座 解决生物医学问题的生物光子学方法，(G)关于学术和工业的小组讨论 职业道路，以及(H)参观学术和工业设施。学员技能的进一步应用和发展 发展将通过一个由导师指导的基于问题的学习项目来实现 完成短期课程一年后。与短期和为期一年的PBL项目并行， 我们将提供技术和专业指导。我们的技术指导旨在支持 生物光子学、仪器和测量设计、技术开发以及建模， 开源计算生物光子学工具的计算和使用。我们的专业导师 该计划旨在帮助受训人员确定适当的短期和长期职业目标并发展 实现这些目标的策略。这门课程是为跨学科的研究生群体、博士后群体而设计的。 博士生、教职员工、科学家和工程师。我们提出了一项积极的外展计划来支持 传统上在STEM内部任职人数不足的受训人员以及来自地域的受训人员的参与 历史上NIH得到的支持水平较低的地区。我们的目标是每个人最多培训20人 年。 综上所述，我们的计划为学员的进步提供了技术基础和指导支持 并应用多尺度生物光子学的综合技术熟练程度来解决生物医学挑战。AS 在生物医学中需要跨越建模、计算和实验的专业知识的集成 在研究和技术开发方面，拟议的计划推进了NIGMS的计划目标 培训一支多样化的生物医学研究队伍，拥有与NIGMS部门最相关的专业知识 生物物理学、生物医学技术和计算生物科学。

PROJECT SUMMARY The overarching objectives and specific aims of this IPERT program are to (1) prepare trainees for successful multi-disciplinary Biophotonics careers and support biomedical workforce development. This will be achieved by (2) advancing the technical and operational proficiency of our trainees in Multiscale Biophotonics through an integration of modeling, computation, experiment, and problem-based learning, and (3) providing our trainees with sustained mentorship for professional development. This will be accomplished by establishing foundational technical and operational skills in the area of Multiscale Biophotonics during a 12-day onsite short course at the University of California, Irvine. This 12-day short course utilizes an integrated modular design and evidence based learning consisting of (a) lectures, (b) technology demonstrations, (c) laboratories combining hands-on data acquisition with computational analysis using our custom Virtual Tissue Simulator (VTS) software platform, (d) Team Science training, (e) mentored capstone problem-based learning (PBL) proposal development, (f) guest lectures on the use of an interdisciplinary Biophotonics approach to address biomedical problems, (g) panel discussions on academic and industrial career paths, and (h) tours of academic and industrial facilities. Further application and growth in trainee skill development will be accomplished by a mentored capstone problem-based learning project to be pursued for one year following the short course completion. In parallel with the short course and year-long PBL project, we will offer both technical and professional mentorship. Our technical mentorship aims to support Biophotonics, instrument and measurement design, technology development, as well as modeling, computation and usage of open-source Computational Biophotonics Tools. Our professional mentorship program aims to aid trainees in identifying appropriate short- and long-term professional goals and develop strategies to attain them. The course has been designed for interdisciplinary group of graduate student, post- doctoral researcher, and faculty scientists and engineers. We propose an aggressive outreach plan to support the participation of trainees who are traditionally underrepresented within STEM as well as from geographic regions that have historically received low levels of NIH support. We aim to train up to 20 individuals each year. In summary, our program provides a technical foundation and mentoring support for trainees to advance and apply an integrated technical proficiency in Multiscale Biophotonics to solve biomedical challenges. As the integration of expertise spanning modeling, computation and experiment are in demand in biomedical research and technology development, the proposed program advances NIGMS programmatic goals for training a diverse biomedical research workforce with expertise most relevant to the NIGMS Division of Biophysics, Biomedical Technology, and Computational Biosciences.