Clinical And Imaging Core Support Of Acute Stroke Research

急性中风研究计划的基础是急性中风临床服务，它将确保最大限度地转介患者，并允许及时地快速识别、筛选和招募潜在的研究对象，以研究脑损伤的早期事件并将患者纳入急性中风研究方案。由于缺乏急诊科，NIH临床中心无法作为我们研究项目的主要地点。因此，我们在当地医院建立并维护了支持这项研究所需的临床、影像和研究基础设施：马里兰州贝塞斯达的郊区医院(SH)和华盛顿特区的MedStar华盛顿医院中心(MWHC)。这些地点也是我们ACGME认证的血管神经学奖学金培训计划的关键培训地点，并被招募到创伤性脑损伤研究方案中。这一基础设施的主要组成部分包括NIH卒中服务，这是NIH和合同工临床医生卒中神经学家、护士、临床研究员、现场研究/护士协调员和核磁共振技术专家的组合。美国国立卫生研究院的计算机网络已经扩展到每个地点。此外，NIH还在MWHC放置了一台3T磁共振扫描仪，并在上海共享了一台3T磁共振扫描仪。我们为MWHC和SH MRI扫描仪上获得的图像维护自己的PAC，并开发和维护临床和研究患者数据的注册表。 冠状病毒大流行在全年继续影响该计划。由于新冠肺炎大流行，我们暂停了研究登记，但我们成功地重新启动了研究，所有研究活动从2020年10月开始。招生和后续工作并不是没有挑战，但该计划已经进行了调整，我们的招募和保留人数与疫情前的水平持平。

The foundation of an acute stroke research program is an acute stroke clinical service that will assure maximum patient referral and allow rapid identification, screening and recruitment of potential research subjects in the timely fashion needed to study the early events in cerebral injury and enroll patients in acute stroke research protocols. Absence of an emergency department has precluded the NIH Clinical Center as the main site of our research projects. Thus, we have established and maintained the clinical, imaging and research infrastructure required to support this research at local hospitals: Suburban Hospital (SH) in Bethesda, Maryland, and MedStar Washington Hospital Center (MWHC) in DC. These sites also serve as the key training locations for our ACGME accredited vascular neurology fellowship training program and for recruitment into the traumatic brain injury research protocols. The major elements of this infrastructure include the NIH Stroke Service, a combination of NIH and contractor clinicians stroke neurologists, nurses, clinical fellows, on-site research/nurse coordinators and MRI technologists. The NIH computer network has been extended to each site. In addition, NIH has placed a 3T MRI scanner at MWHC and shares a 3T MRI scanner at SH. We maintain our own PACS for images obtained on the MWHC and SH MRI scanners, and developed and maintain a registry for clinical and research patient data. The coronavirus pandemic continues to impact the program over the entire year. Enrollment into research was paused due to COVID-19 pandemic, however we successfully reopened the study, with all research activities beginning in October 2020. Enrollment and follow-up have not been without challenges, however the program has adapted and our recruitment and retention number are on par with pre-pandemic levels.