Developmental Funds

项目摘要 科学的领导已经改变了杰克逊实验室癌症中心（JAXCC）在目前的赠款 循环，导致癌症病灶扩大。人类遗传学和基因组学的新专业知识紧密结合 利用小鼠基因组学专业知识，支持人类癌症基因组复杂性建模工作。积分 这种转变是通过教师招聘和现有教师的参与来招募新成员 跨学科的专业知识。JAXCC扩大了其在癌症基因组学方面的能力 和癌症系统生物学，在免疫肿瘤学和肿瘤微环境方面建立了实力， 建立了强大的转化伙伴关系，使基础研究迅速走向临床影响。的 会员人数大幅增加，这是由律师协会和律师协会加强了以癌症为重点的领导层推动的。 海港和法明顿校区，自2013年以来增加了22名新成员（目前有18名 赠款周期）。 发展基金一直是推动JAXCC增长和生产力的关键因素。在当前 赠款周期，新的研究者基金被用来支持九名初级教师，让他们参与 在他们制定研究计划时指导他们的高级领导人。奖项在整个 今年，新的研究人员提交了一份为期两年的奖励正式计划。虽然对大多数人来说还为时过早， 这些初级教员的进步和生产力表明了这种方法的有效性。这些奖项有 支持的工作导致12个出版物和14个外部赠款，总额为5 064 892美元。在下一个周期，资金 将由重要的机构利用新的研究人员奖励， 资金的承诺。计划在未来五年内增加4到5个新的初级JAXCC成员， 持续强调癌症基因组学和免疫肿瘤学。研究将依赖于正在进行的 开发和验证各种体内、离体和计算机模拟系统以模拟癌症复杂性。 试点项目计划是实现JAXCC战略目标的计划的重要组成部分。高级 领导层设定优先事项，并每年通过申请请求（RFA）征求试点提案， 针对具体目标。项目的授予是基于科学的质量，他们的预期贡献， 一个或多个战略目标，以及为成熟项目获得联邦资金的计划。上一 赠款周期，17个奖项支持了14个出版物和14笔赠款，总额为7 619 270美元（直接） 费用）。在头2年内，要求提供资金支持2-3个新的试点项目，向所有JAXCC成员开放 并利用机构匹配。随着会员的成熟，我们将在第3年至第5年资助3-5个试点基金。采取 发展基金将共同支持JAXCC，以促进合作和动态的癌症 能够推进精准癌症医学的计划。

PROJECT SUMMARY DEVELOPMENTAL FUNDS The scientific leadership has transformed The Jackson Laboratory Cancer Center (JAXCC) in the current grant cycle, resulting in an expanded cancer focus. New expertise in human genetics and genomics is tightly integrated with mouse genomics expertise, supporting work to model the complexity of the human cancer genome. Integral to this transformation was recruitment of new members through faculty hiring and engagement of existing faculty with complementary transdisciplinary expertise. The JAXCC has expanded its capabilities in cancer genomics and cancer systems biology, built strength in immuno-oncology and the tumor microenvironment, and established robust translational partnerships to move basic research quickly towards clinical impact. The membership has expanded profoundly, driven by a strengthened, cancer-focused leadership on both the Bar Harbor and Farmington campuses, which saw the addition of 22 new members since 2013 (18 in the current grant cycle). Developmental funds have been crucial factors in fueling the JAXCC's growth and productivity. In the current grant cycle, New Investigator funds were used to support nine junior faculty members, engaging them with the Senior Leaders who mentored them as they developed their research plans. Awards are made throughout the year with new investigators submitting a formal program plan for a two-year award. While still early for most, the progress and productivity of these junior faculty point to the efficacy of this approach. These awards have supported work leading to 12 publications and 14 external grants totaling $5,064,892. In the next cycle, funds are requested for support of new investigator awards, which will be leveraged by significant institutional commitment of funds. Plans call for adding 4 to 5 new junior-level JAXCC members in the next five years, with a continuing emphasis on cancer genomics and immuno-oncology. Research will rely on the ongoing development and validation of a variety of in vivo, ex vivo, and in silico systems to model cancer complexity. The Pilot Project program is an essential part of the plan to achieve the JAXCC's strategic goals. The Senior Leadership sets priorities and solicits pilot proposals annually through a request for applications (RFA) that targets specific goals. Projects are awarded based on the quality of the science, their anticipated contribution to one or more strategic goals, and the plan for securing federal funding for the mature project. In the previous grant cycle, 17 awards have supported work leading to 14 publications and 14 grants totaling $7,619,270 (direct costs). Funds are requested to support 2-3 new pilot projects in the first 2 years, open to all JAXCC members and leveraging institutional match. As the membership matures, we will fund 3-5 pilot funds in years 3 to 5. Taken together, the Developmental Funds will support the JAXCC in fostering a collaborative and dynamic cancer program capable of advancing precision cancer medicine.