Next Generation Antibody Therapeutics

这项研究将集中在一个重要的问题上，即人类抗体的特异性和持久性的局限性。虽然通常被认为是完美的“锁与钥匙”现象，但许多抗体实际上表现出有限的特异性，并与不相关的靶标相互作用，导致短暂的持久性和脱靶效应。通过破译突变和结构机制，解开抗体特异性，我的研究将推动下一代抗体疗法的发展。

This research will focus on an important problem, namely the limitations on specificity and persistence of human antibodies. Although often perceived as a perfect 'lock-and-key' phenomenon, many antibodies in fact display limited specificity and interact with unrelated targets resulting in short persistence and off-target effects. By deciphering mutational and structural mechanisms unpinning antibody specificity, my research will advance the development of next generation antibody therapeutics.