Building Opioid recovery support Networks to engage and retain young adults in Medication for Opioid Use Disorder (BOND)

项目总结/摘要 这一提案是全国禁毒办东北节点的竞争性续期申请 治疗临床试验网络（CTN），于2015年加入CTN。东北节点带来了 新罕布什尔州、佛蒙特州和缅因州的数百个社区和医疗保健合作伙伴， CTN社区第一次这些州是美国药物使用率最高的州之一。 美国，包括阿片类药物的使用，他们包括美国一些最农村的社区。 为CTN带来了重要的专业知识，以进行实用，严格，创新和高度影响力的试验 专注于改善东北部社区系统中物质使用障碍（SUD）的治疗 并与全国其他CTN节点合作。节点调查员在以下方面拥有丰富的经验： 领先的国家和跨国临床试验，数字技术;药物和行为治疗， 阿片类药物使用障碍; SUD与精神健康障碍共病; SUD与慢性疼痛;妊娠期SUD 妇女;阿片类药物、大麻、烟草、酒精、兴奋剂和多种药物治疗; SUD预防和治疗 青年;以及实施科学。东北节点嵌入技术中心 和行为健康（CTBH），一个NIDA资助的P30“卓越中心”。因此，节点带来了重大的 开发，评估和实施SUD数字治疗的专业知识，重点是克服 在地球仪的医疗保健中，治疗的可及性和治疗质量存在显著差异。 在更新期间，该节点建议加强其活动，为国家CTN做出贡献 拥抱科学发现和研究创新的进步，为增加 SUD治疗的范围和有效性。该节点将吸引更广泛的调查人员 带来数据科学（生物信息学、预测建模、人工智能、社交 媒体，数据隐私/安全）和实验设计（微随机试验，自适应设计， 执行/系统科学）。有了这个扩大的合作伙伴集团，它将支持和发展一个富有成效的 CTN的研究议程，重点是（a）数字健康和数据分析，包括重点研究 通过数字技术向SUD患者提供个性化的、基于科学的资源，以及（B） 扩大低门槛获得科学的可持续发展保健，特别是在农村地区（例如，一般 医疗机构;药房;和社区组织）。Node将引领CTN的扩张 关于（c）迅速变化的大麻使用情况以及（d）共同发病的SUD和精神疾病的研究 健康失调该节点将建立社区和政策咨询委员会，以补充现有的 Node调查人员及其合作伙伴之间的通信基础设施，重点是确定 最重要和及时的可持续城市发展的需求，在我们的社区和扩大和维持最佳做法。

Project Summary/Abstract This proposal is a competing renewal application of the Northeast Node of the National Drug Abuse Treatment Clinical Trials Network (CTN), which joined the CTN in 2015. The Northeast Node brought hundreds of community and healthcare partners across the states of New Hampshire, Vermont, and Maine to the CTN community for the first time. These states have among the very highest rates of substance use in the U.S., including opioid use, and they include some of the most rural communities in the U.S. The Node has brought significant expertise to the CTN in conducting practical, rigorous, innovative, and highly impactful trials focused on improving the treatment of substance use disorders (SUDs) in community systems in the Northeast and in partnership with other CTN Nodes across the nation. Node Investigators have extensive experience in leading national and multi-national clinical trials, digital technology; medication and behavioral treatments for opioid use disorder; co-occurring SUDs and mental health disorders; SUD and chronic pain; SUD in pregnant women; opioid, cannabis, tobacco, alcohol, stimulant, and polydrug treatment; SUD prevention and treatment among youth; and implementation science. The Northeast Node is embedded within the Center for Technology and Behavioral Health (CTBH), a NIDA-funded P30 “Center of Excellence”. The Node thus brings significant expertise in developing, evaluating, and implementing digital treatments for SUDs, with a focus on overcoming the striking disparities in treatment access and treatment quality evident in healthcare across the globe. In the renewal period, the Node proposes to enhance its activities and contributions to the national CTN to embrace advances in scientific discovery and research innovations that offer great promise for increasing the reach and effectiveness of treatments for SUDs. The Node will engage a broader group of investigators that bring additional expertise in data science (bioinformatics, predictive modeling, artificial intelligence, social media, data privacy/security) and experimental design (micro-randomized trials, adaptive designs, and implementation/systems science). With this expanded group of partners, it will support and grow a productive research agenda in the CTN with a focus on (a) digital health and data analytics, including research focused on providing personalized, science-based resources to individuals with SUD via digital technology and (b) expanding low threshold access to science-based SUD care, particularly in rural contexts (e.g., general medical settings; pharmacies; and community organizations). And the Node will lead an expansion of CTN research on the (c) rapidly evolving landscape of cannabis use as well as (d) co-morbid SUD and mental health disorders. The Node will establish Community and Policy Advisory Boards to complement the existing communication infrastructure between Node investigators and their partners, with a focus on identifying the most significant and timely SUD needs in our communities and scaling-up and sustaining best practices.