The Vervet Research Colony as Biomedical Resource

项目摘要 本申请是“作为生物医学资源的弗维特研究群体”的行政补充 (VRC，P40-OD 010965）。本申请的目的是获得资金，以支持改建和 翻新（A&R），以增加这种独特的非人类灵长类动物使用的室内动物住房空间 resource. VRC是唯一的NIH资助的生物医学研究资源，为美国出生的长尾/非洲绿色 猴子（AGM; Chlorocebus aethiops sabaeus），自2005年以来一直得到资助。作为动物 和生物材料资源（ABMR），VRC服务于广泛的地方，区域和国家 研究者通过提供动物、生物样本、数据、咨询和与使用 vervets/AGM作为人类疾病的多类别，翻译模型。越南难民委员会促成了关键的 跨各种学科的转化研究，包括：衰老和阿尔茨海默病; 免疫学和疫苗开发;糖尿病、代谢疾病和肥胖症;生物医学成像;以及 基因，除此之外。家长补助金的目的是：1）为科学界提供获得 动物、生物样本、数据和专门知识，以促进将长尾小蠹用于广泛的生物医学 研究; 2）提供特殊的培训机会，并作为社区和 科学推广;和3）通过从事应用研究来加强资源，重点是继续 遗传和表型特征和扩大潜力的vervet作为一个翻译模式，在新的 研究领域。对于这一A&R补充，我们建议设计、建造和安装新型浓缩笼， 改善一部分无法圈养的动物的生理和心理环境 由于临床或实验原因，在物种典型的社会群体中。我们还建议安装红外线 摄像头，以增加这个新的住房面积，以我们现有的24小时监控摄像头系统;并提高感官 和认知丰富。这些努力将加强动物福利和兽医护理，同时也开放 新的研究机会。

PROJECT SUMMARY This application is an administrative supplement to the "Vervet Research Colony as a Biomedical Resource" (VRC, P40-OD010965). The purpose of this application is to obtain funds to support alterations and renovations (A&R) to enhance the indoor animal housing space used by this unique nonhuman primate resource. The VRC is the only NIH-funded biomedical research resource for US-born vervet/African green monkeys (AGM; Chlorocebus aethiops sabaeus) and has been continuously funded since 2005. As an Animal and Biological Material Resource (ABMR), the VRC serves a wide range of local, regional and national investigators by providing animals, biological samples, data, consultation and training pertaining to the use of vervets/AGMs as multi-categorical, translational models of human disease. The VRC has facilitated critical translational research across a wide variety of disciplines, including: aging and Alzheimer's disease; immunology and vaccine development; diabetes, metabolic disease and obesity; biomedical imaging; and genetics, among others. The aims of the parent grant are to: 1) provide the scientific community with access to animals, biological samples, data and expertise to facilitate the use of vervets for a wide-range of biomedical research; 2) to provide exceptional training opportunities, and to serve as a platform for community and scientific outreach; and 3) to enhance the resource by engaging in applied research focused on continuing genetic and phenotypic characterization and expanding potential of the vervet as a translational model in novel research areas. For this A&R supplement, we propose to design, build and install novel enrichment cages that improve the physical and psychosocial environment for a subset of the animal population that can't be housed in species typical social groups due to clinical or experimental reasons. We also propose to install infrared cameras to add this new housing area to our existing 24h surveillance camera system; and to improve sensory and cognitive enrichment. These efforts will enhance animal welfare and veterinary care, while also opening up new research opportunities.